Yang Yang, You Manqing, Luo Lincheng, Wei Hailong
Department of Respiratory and Critical Care Medicine, The People's Hospital of Leshan Leshan 614000, Sichuan, China.
Am J Transl Res. 2025 Jul 25;17(7):5746-5756. doi: 10.62347/MCZH5861. eCollection 2025.
To explore the relationship between nutritional risk and clinical outcomes in patients hospitalized for acute exacerbations of chronic obstructive pulmonary disease COPD (AECOPD).
The medical records of 220 AECOPD patients hospitalized between June 2022 and June 2024 were retrospectively analyzed. The patients were categorized into two groups based on their Nutritional Risk Index (NRI): high-risk ([NRI] < 92) group and low-risk (NRI ≥ 92) group. Clinical outcomes assessed included albumin levels, arterial blood gas parameters, frequency of exacerbations, in-hospital mortality, length of hospital stays, readmission rates, and health-related quality of life (HRQoL). Pulmonary function recovery, including forced expiratory volume in one second (FEV) and forced vital capacity (FVC), was also evaluated post-treatment.
Compared to the low-risk group, patients in the high-risk group exhibited significantly lower albumin levels (P = 0.007), increased frequency of exacerbations (P = 0.005), higher in-hospital mortality (P = 0.004), prolonged hospital stays (P = 0.001), and elevated readmission rates (P = 0.002). High-risk patients also reported significantly lower physical function (PF) and mental health scores. After treatment, improvements in FEV and FVC were significantly greater in the low-risk group (P < 0.05).
Nutritional risk is closely associated with the severity, prognosis, and recurrence of AECOPD. These findings underscore the importance of nutritional assessment and intervention in the management of hospitalized AECOPD patients.
探讨慢性阻塞性肺疾病急性加重期（AECOPD）住院患者营养风险与临床结局之间的关系。
回顾性分析2022年6月至2024年6月期间住院的220例AECOPD患者的病历。根据营养风险指数（NRI）将患者分为两组：高风险（[NRI]<92）组和低风险（NRI≥92）组。评估的临床结局包括白蛋白水平、动脉血气参数、急性加重频率、住院死亡率、住院时间、再入院率以及健康相关生活质量（HRQoL）。治疗后还评估了肺功能恢复情况，包括一秒用力呼气容积（FEV）和用力肺活量（FVC）。
与低风险组相比，高风险组患者的白蛋白水平显著降低（P = 0.007），急性加重频率增加（P = 0.005），住院死亡率更高（P = 0.004），住院时间延长（P = 0.001），再入院率升高（P = 0.002）。高风险患者的身体功能（PF）和心理健康评分也显著较低。治疗后，低风险组的FEV和FVC改善更为显著（P<0.05）。
营养风险与AECOPD的严重程度、预后和复发密切相关。这些发现强调了营养评估和干预在住院AECOPD患者管理中的重要性。
