Intra-articular sodium hyaluronate, compound betamethasone, and ropivacaine combined with arthroscopic debridement in patients with knee osteoarthritis.

OBJECTIVE

To evaluate the efficacy of sodium hyaluronate (SH), compound betamethasone (BT), and ropivacaine (Rop) in combination with arthroscopic debridement (AD) for the treatment of knee osteoarthritis (KOA).

METHODS

A retrospective analysis was conducted on 107 KOA patients treated at Shantou Central Hospital l, including 52 patients in the control group who received AD alone and 55 patients in the observation group who additionally received intra-articular SH, compound BT, and Rop. Treatment efficacy, pain levels, knee joint function, lower limb motor function, serum inflammatory markers, quality of life, and sleep quality were assessed and compared between the two groups. Univariate and multivariate logistic regression analyses were performed to identify factors influencing treatment outcomes.

RESULTS

The observation group showed significantly better outcomes than the control group in terms of overall treatment efficacy, pain relief, improvement in joint and lower limb function, reduction in inflammatory markers, and enhancement of both sleep quality and overall quality of life. Prolonged disease duration was identified as an independent risk factor for poor treatment outcomes.

CONCLUSION

The combination of SH, compound BT, and Rop with AD offers significant clinical advantages in the management of KOA, supporting its broader adoption in clinical practice.