Du Guotu, Huang Xiang, Su Peng, Yang Ying, Chen Shicheng, Huang Tianyu, Zhang Neng
Department of Urology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, China.
Department of Pathology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, China.
Genes Dis. 2025 May 21;12(6):101692. doi: 10.1016/j.gendis.2025.101692. eCollection 2025 Nov.
Prostate cancer remains a major health problem, with its incidence ranking second among male malignancies worldwide. Recent studies have highlighted the critical role of the SOX family transcription factors, especially SOX2, in prostate cancer pathogenesis. SOX2 regulates the fate of cancer stem/progenitor cells, contributing to tumor initiation, development, and metastasis. Elevated SOX2 levels have been detected in prostate cancer tissues and are associated with higher tumor grade, aggressive phenotype, and poor prognosis. SOX2 also impacts various tumor biological behaviors, including cell proliferation, invasion, metastasis, resistance to apoptosis, and treatment resistance. This review highlights the role of SOX proteins in prostate cancer, focusing on the molecular mechanisms by which SOX2 drives cancer progression, elucidating the mechanisms controlling its activity, and emphasizing its potential as a therapeutic target.
前列腺癌仍然是一个重大的健康问题，其发病率在全球男性恶性肿瘤中排名第二。最近的研究强调了SOX家族转录因子，特别是SOX2，在前列腺癌发病机制中的关键作用。SOX2调节癌症干细胞/祖细胞的命运，促进肿瘤的起始、发展和转移。在前列腺癌组织中已检测到SOX2水平升高，且与更高的肿瘤分级、侵袭性表型和不良预后相关。SOX2还影响各种肿瘤生物学行为，包括细胞增殖、侵袭、转移、抗凋亡能力和治疗抗性。本综述重点介绍了SOX蛋白在前列腺癌中的作用，着重探讨SOX2驱动癌症进展的分子机制，阐明控制其活性的机制，并强调其作为治疗靶点的潜力。
