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当体征隐匿时:并存的甲状旁腺腺瘤与无甲状旁腺功能亢进的甲状腺乳头状癌。

When signs are silent: coexisting parathyroid adenoma and papillary thyroid carcinoma without hyperparathyroidism.

作者信息

Arkoumani Maria Kleanthi, Garavellou Maria, Valaora Despoina, Perri Theano, Zografidis Andreas, Lagoudianakis Emmanouel, Mikros Georgios, Karavitis Georgios

机构信息

Second Department of Surgery, 401 Athens General Military Hospital, P. Kanellopoulou Avenue, Athens 115 25, Greece.

Second Department of Surgery, "ARETAIEION" University Hospital of Athens, Vasilissis Sofias Avenue 76, Athens 115 28, Greece.

出版信息

J Surg Case Rep. 2025 Aug 15;2025(8):rjaf625. doi: 10.1093/jscr/rjaf625. eCollection 2025 Aug.

Abstract

Parathyroid adenomas are benign neoplasms of the parathyroid parenchymal cells and the most common cause of primary hyperparathyroidism. The existing literature reporting data on parathyroid adenomas without elevated parathormone and calcium levels is, to our knowledge, limited. The aim of this article is to describe such a case in a patient with coexistent papillary thyroid carcinoma. A 54-year-old female patient presented with a nontoxic multinodular goitre, a nodular lesion in the thyroid isthmus classified as Bethesda V and a lesion behind the left upper thyroid lobe, indicative of parathyroid tumour. There was no clinical or laboratory evidence of hyperparathyroidism. Total thyroidectomy and left upper parathyroidectomy were performed and the histological confirmation of parathyroid adenoma was obtained. This article constitutes a rare case report of a parathyroid adenoma with synchronous papillary thyroid carcinoma but without the expected clinical and laboratory findings of hyperparathyroidism.

摘要

甲状旁腺腺瘤是甲状旁腺实质细胞的良性肿瘤,也是原发性甲状旁腺功能亢进最常见的病因。据我们所知,现有文献中关于甲状旁腺激素和钙水平未升高的甲状旁腺腺瘤的数据有限。本文旨在描述一名合并乳头状甲状腺癌患者的此类病例。一名54岁女性患者,表现为非毒性多结节性甲状腺肿、甲状腺峡部的一个结节性病变,分类为贝塞斯达Ⅴ类,以及左上甲状腺叶后方的一个病变,提示甲状旁腺肿瘤。没有甲状旁腺功能亢进的临床或实验室证据。行全甲状腺切除术和左上甲状旁腺切除术,获得了甲状旁腺腺瘤的组织学确诊。本文构成了一例罕见的甲状旁腺腺瘤合并同步乳头状甲状腺癌但无甲状旁腺功能亢进预期临床和实验室表现的病例报告。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4a8/12354947/0805d8453209/rjaf625f1.jpg

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