Nissim Matan, Shoshani Sivan, Jacobi Gila, Afrimzon Elena, Levy Laura, Banin Ehud, Dombrovsky Aviv, Margel Shlomo
The Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan 5290002, Israel.
Department of Chemistry, Bar-Ilan University, Ramat-Gan 5290002, Israel.
ACS Omega. 2025 Jul 29;10(31):34548-34558. doi: 10.1021/acsomega.5c03160. eCollection 2025 Aug 12.
Although many bacterial species are vital to human health and are important in the food industry, some species lead to disease, which has promoted the development of antibacterial agents to reduce infection and illness. However, antibiotics can be toxic and increase bacterial resistance. Recently, we synthesized new silane-phosphonium monomers to form cross-linked thin coatings on polypropylene films. The produced silica-phosphonium coatings act as antibiofilm and antiviral agents. Here, we prepared and characterized poly-(silane-phosphonium) nanoparticles (NPs) by a modified Stöber polymerization process and characterized them by scanning electron microscopy (SEM), dynamic light scattering (DLS), zeta (ζ) potential, X-ray photoelectron spectroscopy (XPS), and Fourier-transform infrared (FTIR) spectroscopy. These newly formed NPs illustrate great potential in inhibiting (), (), (), (), and the tomato brown rugose fruit virus (ToBRFV). These NPs are toxic to mammalian cells but may have potential use for a variety of agricultural, environmental, and medical applications, as discussed in the article.
尽管许多细菌物种对人类健康至关重要且在食品工业中具有重要意义，但有些物种会导致疾病，这推动了抗菌剂的开发以减少感染和疾病。然而，抗生素可能有毒并会增加细菌耐药性。最近，我们合成了新的硅烷 - 鏻单体，以在聚丙烯薄膜上形成交联薄涂层。所制备的二氧化硅 - 鏻涂层可作为抗生物膜和抗病毒剂。在此，我们通过改进的Stöber聚合工艺制备并表征了聚（硅烷 - 鏻）纳米颗粒（NPs），并通过扫描电子显微镜（SEM）、动态光散射（DLS）、zeta（ζ）电位、X射线光电子能谱（XPS）和傅里叶变换红外（FTIR）光谱对其进行了表征。这些新形成的纳米颗粒在抑制（）、（）、（）、（）和番茄褐色皱纹果病毒（ToBRFV）方面显示出巨大潜力。如本文所述，这些纳米颗粒对哺乳动物细胞有毒，但可能在各种农业、环境和医学应用中具有潜在用途。
