Rauws A G
Tijdschr Diergeneeskd. 1985 Nov 15;110(22):932-4.
The disappearance of drug residues from slaughter animals treated by intramuscular route can only be reliably predicted when the dose is rapidly and reproducibly absorbed. In actual practice, this will frequently not be the case. The effects of slow absorption for extinction of residues are illustrated by pharmacokinetic simulation. It is concluded that withdrawal times should not be determined for a drug substance but for any intramuscular formulation of that substance.
只有当剂量能够快速且可重复地被吸收时，才能可靠地预测通过肌肉注射途径治疗的屠宰动物体内药物残留的消失情况。在实际操作中，情况往往并非如此。药代动力学模拟说明了吸收缓慢对残留消除的影响。得出的结论是，不应针对某一药物物质确定停药期，而应针对该物质的任何肌肉注射制剂来确定。
