Sato A, Endo C, Kyozuka M, Liou S M, Idogawa T, Saito J, Akagi K, Yamaguchi Y, Suzuki M
Tohoku J Exp Med. 1985 Oct;147(2):157-68. doi: 10.1620/tjem.147.157.
During the period between 1980 and 1983, a versatile experimental model for fetal physiology (chronic fetal preparation) was made using 26 pregnant Corriedale and Suffolk sheep. The sheep fetuses were removed from the uterus at the gestational ages of from 96 to 133 days. After performing cannulation of the carotid arteries, the jugular veins , and the trachea of the fetuses, applying tripolar cardioelectrodes, and attaching an occluder of the umbilical cord, the fetuses were returned to the uterus to complete the gestational period. The time left until the termination of the postoperative pregnancy and available for various intrauterine monitoring procedures varied from 3 to 800 hr. Eleven sheep (42.3%) continued their postoperative intrauterine term for 5 days or more. The continuation of the postoperative gestation for longer than 5 days indicated a return to the physiological state on the evidence of the measured PO2, PCO2 and pH values and rapid irregular breathing movements.
1980年至1983年期间，利用26只怀孕的考力代羊和萨福克羊制作了一种用于胎儿生理学的通用实验模型（慢性胎儿制备）。在妊娠96至133天时，将羊胎儿从子宫中取出。在对胎儿的颈动脉、颈静脉和气管进行插管，应用三极心脏电极，并连接脐带封堵器后，将胎儿放回子宫以完成妊娠期。术后妊娠终止前可用于各种宫内监测程序的剩余时间从3小时到800小时不等。11只羊（42.3%）术后在子宫内持续了5天或更长时间。术后妊娠持续超过5天表明，根据测得的氧分压、二氧化碳分压和pH值以及快速不规则呼吸运动的证据，已恢复到生理状态。
