Wang Jiayun, Yan Zhiqiang, Zhang Xinxin, Wang Shun, Jiao Liangbo, Zhu Binghua, Tan Bo, Yang Aidong
The Research Center for Traditional Chinese Medicine, Shanghai Institute of Infectious Diseases and Biosecurity, School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Clinical Pharmacokinetic Laboratory, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Front Pharmacol. 2025 Jul 31;16:1592458. doi: 10.3389/fphar.2025.1592458. eCollection 2025.
Acute Lung Injury (ALI) is a severe and progressive condition characterized by hypoxic respiratory failure, often triggered by multiple contributing factors. It is associated with high morbidity and mortality rates and can advance to Acute Respiratory Distress Syndrome (ARDS) in severe cases. The pathogenesis of ALI involves a complex interplay of pathological mechanisms, including immune-inflammatory responses, disruption of the alveolar-capillary barrier, damage to mesenchymal stem cell organelles, metabolic dysregulation, ferroptosis, and alterations in gut microbiota. From the perspective of Traditional Chinese Medicine (TCM), the development of ALI is primarily attributed to the invasion of toxic pathogens, which result in lung dysfunction. TCM treatment strategies, which emphasize heat-clearing, detoxification, promoting blood circulation, and resolving stasis, have demonstrated promising clinical efficacy. This paper provides a comprehensive analysis of the pathogenesis of ALI and explores the therapeutic mechanisms of TCM compounds and bioactive monomers with potential therapeutic benefits. The goal is to establish a solid theoretical foundation for the clinical application of TCM in ALI treatment and to further validate its scientific rationale.
急性肺损伤（ALI）是一种严重且进行性的病症，其特征为低氧性呼吸衰竭，通常由多种促成因素引发。它与高发病率和死亡率相关，在严重情况下可进展为急性呼吸窘迫综合征（ARDS）。ALI的发病机制涉及多种病理机制的复杂相互作用，包括免疫炎症反应、肺泡 - 毛细血管屏障破坏、间充质干细胞细胞器损伤、代谢失调、铁死亡以及肠道微生物群改变。从中医角度来看，ALI的发生主要归因于毒邪侵袭，导致肺功能失调。强调清热、解毒、活血化瘀的中医治疗策略已显示出有前景的临床疗效。本文对ALI的发病机制进行了全面分析，并探讨了具有潜在治疗益处的中药复方和生物活性单体的治疗机制。目的是为中医在ALI治疗中的临床应用建立坚实的理论基础，并进一步验证其科学依据。
