The MOE Key Laboratory of Standardization of Chinese Medicines, the SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicine, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
The MOE Key Laboratory of Standardization of Chinese Medicines, the SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicine, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Phytomedicine. 2024 Dec;135:155562. doi: 10.1016/j.phymed.2024.155562. Epub 2024 Mar 22.
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are the leading causes of acute respiratory failure in many critical diseases and are among the main respiratory diseases with high clinical mortality. The global outbreak of coronavirus disease 2019 (COVID-19) can cause severe ARDS, resulting in a steep rise in the number of patient deaths. Therefore, it is important to explore the pathogenesis of ALI and find effective therapeutic agents. In recent years, thanks to modern biomedical tools, some progress has been made in the application of traditional Chinese medicine (TCM) treatment principles based on syndromic differentiation and holistic concepts in clinical and experimental studies of ALI. More and more TCM effective components and formulae have been verified to have significant curative effects, which have a certain guiding significance for clinical practice.
It is hoped to provide reference for the clinical research of ALI/ARDS and provide theoretical basis and technical support for the scientific application of TCM in respiratory related diseases.
We performed a literature survey using traditional books of Chinese medicine and online scientific databases including PubMed, Web of Science, Google Scholar, ScienceDirect, China National Knowledge Infrastructure (CNKI), and others up to January 2023.
In recent years, thanks to modern biomedical tools, some progress has been made in the application of TCM treatment principles based on syndromic differentiation and holistic concepts in clinical and experimental studies of ALI. This paper mainly reviews the research progress of ALI/ARDS mechanism, the understanding of its etiology and pathogenesis by TCM, and the therapeutic effects of TCM formulae and active ingredients of Chinese medicine. A large number of studies have shown that the effective components and formulae of TCM can prevent or treat ALI/ARDS in vivo and in vitro experiments.
TCM effective components and formulae play an important role in the prevention and treatment of ALI/ARDS through multiple approaches and multiple targets, and provide necessary theoretical support for the further development and utilization of TCM resources.
急性肺损伤（ALI）和急性呼吸窘迫综合征（ARDS）是许多危重病导致急性呼吸衰竭的主要原因，也是临床死亡率较高的主要呼吸系统疾病之一。2019 年冠状病毒病（COVID-19）的全球爆发可导致严重的 ARDS，导致患者死亡人数急剧上升。因此，探索 ALI 的发病机制并寻找有效的治疗药物非常重要。近年来，由于现代生物医学工具的应用，基于证候辨证和整体观念的中医药治疗原则在 ALI 的临床和实验研究中取得了一些进展。越来越多的中药有效成分和方剂已被证明具有显著疗效，这对临床实践具有一定的指导意义。
为 ALI/ARDS 的临床研究提供参考，为中医药在呼吸相关疾病中的科学应用提供理论基础和技术支持。
我们检索了传统中医书籍和包括 PubMed、Web of Science、Google Scholar、ScienceDirect、中国知网（CNKI）在内的在线科学数据库，检索时间截至 2023 年 1 月。
近年来，由于现代生物医学工具的应用，基于证候辨证和整体观念的中医药治疗原则在 ALI 的临床和实验研究中取得了一些进展。本文主要综述了 ALI/ARDS 机制的研究进展、中医药对其病因病机的认识、以及中药方剂和中药有效成分的治疗作用。大量研究表明，中药有效成分和方剂可在体内和体外实验中预防或治疗 ALI/ARDS。
中药有效成分和方剂通过多种途径和多个靶点在防治 ALI/ARDS 中发挥重要作用，为进一步开发和利用中医药资源提供了必要的理论支持。
