Singh Shelly, Swain Jnana Ranjan, Gugnani Megha, Arya Ashtha, Baghel Ranjita Singh, Shafique Samra
Department of Dental Surgery, School of Dental Medicine, University of Colorado, USA.
Department of Pedodontics and Preventive Dentistry, Institute of Dental Sciences, Siksha O Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India.
Bioinformation. 2025 May 31;21(5):1195-1200. doi: 10.6026/973206300211195. eCollection 2025.
The efficacy of nano-hydroxyapatite (nHA) alone and in combination with platelet-rich fibrin (PRF) in enhancing periapical bone healing following endodontic retreatment is of interest. Thirty-two patients with failed endodontic treatment in anterior teeth were divided into two groups. After retreatment, apicoectomy and root-end filling with mineral trioxide aggregate (MTA) were performed. Group 1 received nHA alone, while Group 2 received a combination of nHA and PRF in the periapical cavity. Follow-ups at 1, 3, and 6 months showed significant lesion size reduction in both groups, with faster healing in the nHA+PRF group at 1 month, but no long-term differences.
单独使用纳米羟基磷灰石(nHA)以及将其与富血小板纤维蛋白(PRF)联合使用,在根管再治疗后促进根尖周骨愈合方面的疗效备受关注。32例前牙根管治疗失败的患者被分为两组。再治疗后,进行根尖切除术并用三氧化矿物凝聚体(MTA)进行根充。第1组仅接受nHA,而第2组在根尖周腔内接受nHA与PRF的联合治疗。1个月、3个月和6个月的随访显示,两组的病变大小均显著减小,nHA+PRF组在1个月时愈合更快,但无长期差异。