Xie Mingjie, Huang Liuyun, Li Ling, Qin Yuanyuan, Feng Biheng, Cai Qingjiang, Huang Debin
Department of Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Guangxi Clinical Research Center for Critical Care Medicine, Nanning, China.
Front Nutr. 2025 Jul 31;12:1654901. doi: 10.3389/fnut.2025.1654901. eCollection 2025.
PURPOSE: This study aimed to explore the association between the Nutrition Risk in Critical Illness (NUTRIC) score and the risk of ICU mortality in patients with sepsis. METHODS: This was a single-center, prospective cohort study that enrolled septic patients admitted between November 2024 and May 2025 to Wards 1 and 2 of the Department of Critical Care Medicine at the First Affiliated Hospital of Guangxi Medical University. A multivariable logistic regression model was applied to evaluate the association between the NUTRIC score assessed within 24 h of ICU admission and ICU mortality. Restricted cubic spline (RCS) analysis was conducted to model this relationship, and robustness was verified via subgroup analysis. Kaplan-Meier survival curve analysis was used to compare cumulative ICU survival rates among different NUTRIC score groups, with differences between groups tested using the log-rank test. RESULTS: A total of 245 patients with sepsis were included in the study, and the ICU mortality rate was 17.1% (42/245). Multivariable logistic regression showed a statistically significant association between the NUTRIC score and ICU mortality, with each 1-point increase in the score associated with a 92% increase in risk (OR = 1.92, 95% CI: 1.32-2.80, = 0.002). RCS analysis indicated a significant linear relationship between the NUTRIC score and ICU mortality risk (P = 0.704). Subgroup analysis further demonstrated a positive association across all subgroups (ORs > 1), and did not identify any significant interactions. Kaplan-Meier survival curves showed that patients with high nutritional risk (NUTRICb group) had significantly poorer ICU survival than those with low nutritional risk (NUTRICa group) (log-rank test, = 0.00024). CONCLUSION: The NUTRIC score is significantly associated with ICU mortality in patients with sepsis, highlighting its potential utility in early ICU risk stratification. Incorporating the NUTRIC score into ICU assessment protocols may help identify high-risk patients early and guide early nutrition or supportive care, potentially improving clinical outcomes.
目的：本研究旨在探讨危重症营养风险（NUTRIC）评分与脓毒症患者重症监护病房（ICU）死亡风险之间的关联。 方法：这是一项单中心前瞻性队列研究，纳入了2024年11月至2025年5月期间入住广西医科大学第一附属医院重症医学科1病区和2病区的脓毒症患者。应用多变量逻辑回归模型评估ICU入院24小时内评估的NUTRIC评分与ICU死亡率之间的关联。进行受限立方样条（RCS）分析以模拟这种关系，并通过亚组分析验证稳健性。采用Kaplan-Meier生存曲线分析比较不同NUTRIC评分组之间的累积ICU生存率，组间差异采用对数秩检验。 结果：本研究共纳入245例脓毒症患者，ICU死亡率为17.1%（42/245）。多变量逻辑回归显示NUTRIC评分与ICU死亡率之间存在统计学显著关联，评分每增加1分，风险增加92%（OR = 1.92，95% CI：1.32 - 2.80，P = 0.002）。RCS分析表明NUTRIC评分与ICU死亡风险之间存在显著线性关系（P = 0.704）。亚组分析进一步表明所有亚组之间均存在正相关（OR > 1），且未发现任何显著的相互作用。Kaplan-Meier生存曲线显示，高营养风险患者（NUTRICb组）的ICU生存率显著低于低营养风险患者（NUTRICa组）（对数秩检验，P = 0.00024）。 结论：NUTRIC评分与脓毒症患者的ICU死亡率显著相关，突出了其在ICU早期风险分层中的潜在效用。将NUTRIC评分纳入ICU评估方案可能有助于早期识别高危患者并指导早期营养或支持治疗，从而可能改善临床结局。
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