Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
J Crit Care. 2022 Oct;71:154096. doi: 10.1016/j.jcrc.2022.154096. Epub 2022 Jul 12.
The aim of this study was to examine the quality of manuscripts reporting sepsis health care costs and to provide an overview of hospital-related expenditures for sepsis in adult patients around the world.
We systematically searched the PubMed, EMBASE, Cochrane and Google Scholar to identify relevant studies between January 2010 and January 2022. We selected articles that provided costs and cost-effectiveness analyses, defined sepsis and described their cost calculation method. All costs were adjusted to 2020 US dollars. Medians and interquartile ranges (IQRs) for various costs of sepsis were calculated. The quality of economic studies was assessed using the Drummond 10-item checklist.
Overall, 26 studies met our eligibility criteria. The mean total hospital costs per patient varied largely, between €1101 and €91,951. The median (IQR) of the total sepsis costs per country were €36,191 (€17,158 - €53,349), which equals €50 (€34 - €84) per capita annually. The relative amount of healthcare budget spent on sepsis was 2.65%, which equals 0.33% of the gross national product (GNP).
While general sepsis costs are high, there is considerable variability between countries regarding the costs of sepsis. Further studies examining the impact on sepsis costs, especially on the general ward, can help justify, design and monitor initiatives on prevention, diagnosis, and treatment of this time-critical and potentially preventable disease.
本研究旨在评估报告脓毒症医疗保健费用的研究文献质量，并对全球成年脓毒症患者的医院相关支出进行概述。
我们系统地检索了 PubMed、EMBASE、Cochrane 和 Google Scholar，以确定 2010 年 1 月至 2022 年 1 月期间的相关研究。我们选择了提供成本和成本效益分析、定义脓毒症并描述其成本计算方法的文章。所有成本均按 2020 年美元进行调整。计算了各种脓毒症成本的中位数和四分位距（IQR）。使用 Drummond 10 项清单评估经济研究的质量。
共有 26 项研究符合纳入标准。每位患者的平均总住院费用差异很大，为 1101 欧元至 91951 欧元。每个国家的总脓毒症成本中位数（IQR）为 36191 欧元（17158-53349 欧元），相当于人均每年 50 欧元（34-84 欧元）。用于脓毒症的医疗保健预算的相对金额为 2.65%，相当于国民生产总值（GNP）的 0.33%。
尽管总体脓毒症费用较高，但各国之间脓毒症费用存在相当大的差异。进一步研究脓毒症成本的影响，特别是在普通病房，可以帮助证实、设计和监测预防、诊断和治疗这种时间紧迫且可能可预防的疾病的措施。
