Hua Yunqi, Zhang Gangling, Liu Yubo, Tian Xiaoling, Zhang Xinyi, Song Ge, Tian Qinggang, Yin Fangrui
Department of Medical Oncology, Baotou Cancer Hospital, Baotou, Inner Mongolia, China.
Department of Graduate School, Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, China.
Front Oncol. 2025 Jul 31;15:1604227. doi: 10.3389/fonc.2025.1604227. eCollection 2025.
In recent years, the role of sphingolipid metabolism in the tumor immune microenvironment has gradually gained attention, particularly in gastric cancer research. Sphingolipids are crucial components of cell membranes that regulate cell signaling and immune responses, making them important in tumor biology research. Despite numerous studies exploring the relationship between sphingolipid metabolism and gastric cancer, the specific regulatory mechanisms remain unclear. Further investigation is needed to understand their roles in the immune microenvironment. This article aims to review the regulatory mechanisms of sphingolipid metabolism in the immune microenvironment of gastric cancer, discussing its potential applications in tumor occurrence, development, and treatment. By analyzing current research progress, we will clarify the complex relationship between sphingolipid metabolism and immune cell interactions and look forward to future research directions, hoping to provide new ideas and strategies for immunotherapy in gastric cancer.
近年来，鞘脂代谢在肿瘤免疫微环境中的作用逐渐受到关注，尤其是在胃癌研究领域。鞘脂是细胞膜的关键组成部分，可调节细胞信号传导和免疫反应，这使其在肿瘤生物学研究中具有重要意义。尽管有大量研究探讨鞘脂代谢与胃癌之间的关系，但其具体调控机制仍不清楚。需要进一步研究以了解它们在免疫微环境中的作用。本文旨在综述胃癌免疫微环境中鞘脂代谢的调控机制，讨论其在肿瘤发生、发展和治疗中的潜在应用。通过分析当前的研究进展，我们将阐明鞘脂代谢与免疫细胞相互作用之间的复杂关系，并展望未来的研究方向，希望为胃癌免疫治疗提供新的思路和策略。
