Karawita Janadi, Kabachi Faiza Yasmine, Modak Aliya, Venkiteswaran Arun, Haseeb Rawiah, Papiashvili Nikoloz, Jacob Kevin, Abralava Veriko
Faculty of Medicine, Tbilisi State Medical University, Tbilisi, Georgia.
Expert Rev Clin Immunol. 2025 Sep;21(9):1287-1295. doi: 10.1080/1744666X.2025.2549826. Epub 2025 Aug 25.
Atopic dermatitis (AD) is a chronic inflammatory skin condition prevalent among children worldwide. Systemic inflammation is a key factor in its pathophysiology. Correlating blood markers with Eczema Area and Severity Index (EASI) can reveal information about the severity and activity of the disorder, allowing for more focused treatment.
A retrospective analysis was conducted on 22 patients aged 3 months to 18 years. Blood parameters, such as Eosinophil Relative Count (ERC), Neutrophil/Lymphocyte Ratio (NLR), Eosinophil/Lymphocyte Ratio (ELR), and Basophil/Lymphocyte Ratio (BLR), were correlated with the Eczema Area and Severity Index (EASI).
A strong positive correlation was observed between EASI scores and ERC ( = 0.69, < 0.001) and with ELR ( = 0.71, < 0.001). No statistical significance was seen between EASI scores and the NLR ( = 0.2059, = 0.3578) and BLR ( = 0.1026, = 0.6494). No significant association was found between age and EASI scores ( = -0.0351, = 0.8767).
ERC and ELR have the potential to serve as objective blood markers for assessing AD severity. However, more research in pediatric populations with a larger sample size is needed to establish a conclusive association for clinical practice.
特应性皮炎（AD）是一种在全球儿童中普遍存在的慢性炎症性皮肤病。全身炎症是其病理生理学的关键因素。将血液标志物与湿疹面积和严重程度指数（EASI）相关联，可以揭示有关该疾病严重程度和活动情况的信息，从而实现更有针对性的治疗。
对22例年龄在3个月至18岁之间的患者进行了回顾性分析。将血液参数，如嗜酸性粒细胞相对计数（ERC）、中性粒细胞/淋巴细胞比值（NLR）、嗜酸性粒细胞/淋巴细胞比值（ELR）和嗜碱性粒细胞/淋巴细胞比值（BLR），与湿疹面积和严重程度指数（EASI）进行关联分析。
观察到EASI评分与ERC（=0.69，<0.001）和ELR（=0.71，<0.001）之间存在强正相关。EASI评分与NLR（=0.2059，=0.3578）和BLR（=0.1026，=0.6494）之间无统计学意义。年龄与EASI评分之间未发现显著关联（= -0.0351，=0.8767）。
ERC和ELR有可能作为评估AD严重程度的客观血液标志物。然而，需要对更大样本量的儿科人群进行更多研究，以建立用于临床实践的确定性关联。
