Zhang Haiying, Zhao Yang, Chen Yi, Feng Yuanyuan, Shen Bo, Dong Shuangshuang, Zhu Jun, Jiang Xu, Li Dongfeng, Chen Yaning, Han Feng, Zhang Li
Department of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, China.
School of Pharmacy, Nanjing Medical University, Nanjing, China.
NPJ Parkinsons Dis. 2025 Aug 18;11(1):244. doi: 10.1038/s41531-025-01106-9.
Minor hallucinations (MH), comprising three subtypes (presence hallucinations, passage hallucinations, and visual illusions), typically emerge during the early stages of Parkinson's disease (PD) and precede the onset of well-structured visual hallucinations (VH). Whether the number of MH is associated with VH in PD patients remains unclear. We investigated the association between the number of MH and VH in 372 PD patients. Log-binomial regressions showed that individuals with multiple MH had a significantly higher prevalence of VH (RR = 2.08, 95% CI: 1.11-3.90 for 2 MH; RR = 6.20, 95% CI: 3.40-11.31 for 3 MH), while those with only one MH had a similar VH prevalence compared to those without MH (RR = 1.08, 95% CI: 0.53-2.21). Women exhibited stronger associations than men. These findings emphasize the importance of quantifying MH subtypes when assessing hallucinations, though their potential utility as predictive markers of disease progression and targets for early intervention requires validation through longitudinal studies.
轻微幻觉（MH）包括三种亚型（存在性幻觉、路过性幻觉和视错觉），通常在帕金森病（PD）的早期阶段出现，并先于结构完整的视幻觉（VH）发作。PD患者中MH的数量是否与VH相关仍不清楚。我们调查了372例PD患者中MH数量与VH之间的关联。对数二项回归显示，有多个MH的个体VH患病率显著更高（2个MH时RR = 2.08，95%CI：1.11 - 3.90；3个MH时RR = 6.20，95%CI：3.40 - 11.31），而只有一个MH的个体与没有MH的个体相比，VH患病率相似（RR = 1.08，95%CI：0.53 - 2.21）。女性的关联比男性更强。这些发现强调了在评估幻觉时量化MH亚型的重要性，尽管它们作为疾病进展预测标志物和早期干预靶点的潜在效用需要通过纵向研究来验证。
