Qin Geng, Liu Huan, Zhang Xueyu, Li Wei, Guo Yuxing, Guo Chuanbin
IEEE Trans Image Process. 2025;34:5414-5428. doi: 10.1109/TIP.2025.3598499.
Hyperspectral imaging technology is considered a new paradigm for high-precision pathological image segmentation due to its ability to obtain spatial and spectral information of the detected object simultaneously. However, due to the time-consuming and laborious manual annotation, precise annotation of medical hyperspectral images is difficult to obtain. Therefore, there is an urgent need for a semi-supervised learning framework that can fully utilize unlabeled data for medical hyperspectral image segmentation. In this work, we propose an adversarial consistency constraint learning cross indication network (ACCL-CINet), which achieves accurate pathological image segmentation through adversarial consistency constraint learning training strategies. The ACCL-CINet comprises a contextual and structural encoder to form the spatial-spectral feature encoding part. The contextual and structural indications are aggregated into features through a cross indication attention module and finally decoded by a pixel decoder to generate prediction results. For the semi-supervised training strategy, a pixel perceptual consistency module encourages the two models to generate consistent and low-entropy predictions. Secondly, a pixel maximum neighborhood probability adversarial constraint strategy is designed, which produces high-quality pseudo labels for cross supervision training. The proposed ACCL-CINet has been rigorously evaluated on both public and private datasets, with experimental results demonstrating that it outperforms state-of-the-art semi-supervised methods. The code is available at: https://github.com/Qugeryolo/ACCL-CINet.
高光谱成像技术因其能够同时获取被检测物体的空间和光谱信息,而被视为高精度病理图像分割的一种新范式。然而,由于手动标注耗时费力,医学高光谱图像的精确标注难以获得。因此,迫切需要一种能够充分利用未标注数据进行医学高光谱图像分割的半监督学习框架。在这项工作中,我们提出了一种对抗一致性约束学习交叉指示网络(ACCL-CINet),它通过对抗一致性约束学习训练策略实现精确的病理图像分割。ACCL-CINet包括一个上下文和结构编码器,以形成空间光谱特征编码部分。上下文和结构指示通过交叉指示注意力模块聚合为特征,最后由像素解码器解码以生成预测结果。对于半监督训练策略,一个像素感知一致性模块鼓励两个模型生成一致且低熵的预测。其次,设计了一种像素最大邻域概率对抗约束策略,该策略为交叉监督训练生成高质量的伪标签。所提出的ACCL-CINet已在公共和私有数据集上进行了严格评估,实验结果表明它优于现有的半监督方法。代码可在以下网址获取:https://github.com/Qugeryolo/ACCL-CINet。