Guyonnet Sophie, Hooper Claudie, Cantet Christelle, Coley Nicola, Andrieu Sandrine, Vellas Bruno, Lipsitz Lewis A
Department of Geriatrics, Institute Hospital-Universitaire (IHU) HealthAge, Gérontopôle, CHU Toulouse, Toulouse, France.
CERPOP, INSERM UMR, University of Toulouse, Toulouse, France.
J Gerontol A Biol Sci Med Sci. 2025 Aug 23;80(9). doi: 10.1093/gerona/glaf181.
The "INStitute for Prevention," "healthy agIng," and "medicine REjuvenative" "Translational" (INSPIRE-T) study is a 10-year observational study. The primary objective of which is to study trajectories of aging across lifespan from the perspective of intrinsic capacity (IC) through deep clinical and biological phenotyping.
IC was assessed in the INSPIRE-T cohort stratified by age (10-year age groups) using the World Health Organization (WHO) integrated care for older people (ICOPE) program. Biospecimens (biofluids, dental plaque, nasopharyngeal swabs, stools, hair follicles, and skin biopsies) were also collected for biomarker studies and drug-target identification for the prediction and prevention of IC declines respectively.
The INSPIRE-T baseline data is presented including demographic, health, anthropometric, lifestyle, and IC characteristics of the cohort. The open cohort (ongoing recruitment) currently consists of 1109 participants with data available at baseline (61.9% female) aged from 20 to 102 years old (mean age ± standard deviation: 62.4 ± 19.0 years). The most prevalent IC abnormalities identified using ICOPE Step 1. screening appeared to be in vision (89.3%), audition (30.5%), and cognition (24.7%) in the total baseline population, while locomotor capacity abnormalities (5.4%) appeared to be the least frequent. Sex-specific differences were observed for the domains of psychological well-being, audition, vitality in 30-39-year olds and vision in subjects ≤39 years old.
The ultimate goal of INSPIRE-T is to enable the identification of individuals at risk of IC declines in order to implement personalized preventive interventions to promote healthy aging.
“预防研究所”“健康老龄化”和“医学复兴”“转化”（INSPIRE-T）研究是一项为期10年的观察性研究。其主要目的是通过深入的临床和生物学表型分析，从内在能力（IC）的角度研究整个生命周期的衰老轨迹。
在INSPIRE-T队列中，使用世界卫生组织（WHO）老年人综合照护（ICOPE）计划，按年龄（10岁年龄组）分层评估IC。还收集了生物标本（生物流体、牙菌斑、鼻咽拭子、粪便、毛囊和皮肤活检组织），分别用于生物标志物研究和药物靶点鉴定，以预测和预防IC下降。
展示了INSPIRE-T基线数据，包括队列的人口统计学、健康状况、人体测量学、生活方式和IC特征。开放队列（正在招募）目前由1109名参与者组成，他们在基线时有可用数据（61.9%为女性），年龄在20至102岁之间（平均年龄±标准差：62.4±19.0岁）。在整个基线人群中，使用ICOPE第一步筛查确定的最常见IC异常似乎是视力（89.3%）、听力（30.5%）和认知（24.7%），而运动能力异常（5.4%）似乎是最不常见的。在30-39岁人群的心理健康、听力、活力领域以及≤39岁受试者的视力方面观察到了性别差异。
INSPIRE-T的最终目标是能够识别有IC下降风险的个体，以便实施个性化预防干预措施来促进健康老龄化。
