Rissanen A M
Acta Med Scand. 1985;218(4):355-63. doi: 10.1111/j.0954-6820.1985.tb08859.x.
Occurrence of different clinical manifestations of coronary heart disease (CHD) was assessed among the parents and siblings of 309 men with CHD (case probands), including 103 men with fatal and 100 with nonfatal myocardial infarction (MI), and 106 men with angina pectoris (AP) and among the relatives of 106 reference men. CHD was equally common among relatives of all case probands. It was four times as common in case brothers and twice as common in case sisters as in the respective reference siblings. There were differences between the various case groups as to the predominant clinical manifestation of CHD. Cardiac deaths were commonest in the sibs of men with fatal MI, and uncomplicated angina in the men with AP. The familial resemblance in the clinical manifestations of CHD suggests familial influence in the mechanisms determining the clinical expression of the disease.
在309例冠心病（CHD）男性患者（病例先证者）的父母及兄弟姐妹中评估冠心病不同临床表现的发生率，其中包括103例致命性心肌梗死男性患者、100例非致命性心肌梗死（MI）男性患者、106例心绞痛（AP）男性患者，以及106例对照男性的亲属。冠心病在所有病例先证者的亲属中同样常见。在病例组的兄弟中，冠心病的发生率是相应对照兄弟姐妹的4倍，在病例组的姐妹中则是2倍。不同病例组之间冠心病的主要临床表现存在差异。心脏性死亡在致命性心肌梗死男性患者的兄弟姐妹中最为常见，而单纯性心绞痛在心绞痛男性患者中最为常见。冠心病临床表现中的家族相似性表明家族因素在决定该疾病临床表型的机制中发挥作用。
