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IL2RG knockout mitigates polycystic ovary syndrome pathogenesis by transitioning pyroptosis to apoptosis through the GSDME pathway.

作者信息

Chen Sailing, Lu Han, Ying Yingfen, Xi Haitao, Zheng Jingyi, Gong Chaochao, Wang Shaowei, Tang Yunbin, Zhao Junzhao, Ge Ren-Shan, Li Xiaoheng

机构信息

Department of Obstetrics and Gynecology, the Second Affiliated Hospital, Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, China.

Department of Obstetrics and Gynecology, Reproductive Medicine Center, The Second Affiliated Hospital of Wenzhou Medical University, 325027, Wenzhou, China.

出版信息

J Ovarian Res. 2025 Aug 19;18(1):189. doi: 10.1186/s13048-025-01774-4.

DOI:10.1186/s13048-025-01774-4
PMID:40830889
Abstract
摘要

相似文献

1
IL2RG knockout mitigates polycystic ovary syndrome pathogenesis by transitioning pyroptosis to apoptosis through the GSDME pathway.IL2RG基因敲除通过GSDME途径将细胞焦亡转变为凋亡，从而减轻多囊卵巢综合征的发病机制。
J Ovarian Res. 2025 Aug 19;18(1):189. doi: 10.1186/s13048-025-01774-4.
2
Gut microbiota dysbiosis-derived macrophage pyroptosis causes polycystic ovary syndrome via steroidogenesis disturbance and apoptosis of granulosa cells.肠道菌群失调导致的巨噬细胞焦亡通过干扰类固醇生成和颗粒细胞凋亡引起多囊卵巢综合征。
Int Immunopharmacol. 2022 Jun;107:108717. doi: 10.1016/j.intimp.2022.108717. Epub 2022 Mar 22.
3
GSDME promotes MASLD by regulating pyroptosis, Drp1 citrullination-dependent mitochondrial dynamic, and energy balance in intestine and liver.GSDME 通过调节细胞焦亡、依赖 Drp1 瓜氨酸化的线粒体动态以及肠和肝中的能量平衡来促进 MASLD。
Cell Death Differ. 2024 Nov;31(11):1467-1486. doi: 10.1038/s41418-024-01343-0. Epub 2024 Jul 16.
4
GSDMD and GSDME exhibit distinct roles in enteric coronavirus PDCoV-induced pyroptosis and inflammatory responses.Gasdermin D（GSDMD）和Gasdermin E（GSDME）在肠道冠状病毒猪德尔塔冠状病毒（PDCoV）诱导的细胞焦亡和炎症反应中发挥不同作用。
J Virol. 2025 Jul 22;99(7):e0187624. doi: 10.1128/jvi.01876-24. Epub 2025 Jun 12.
5
Paeoniflorin protected UVA-exposed skin fibroblasts from caspase-3/GSDME mediated pyroptosis.芍药苷可保护UVA照射的皮肤成纤维细胞免受caspase-3/GSDME介导的细胞焦亡。
J Photochem Photobiol B. 2025 Aug;269:113188. doi: 10.1016/j.jphotobiol.2025.113188. Epub 2025 May 28.
6
Phosphorylated IRF3 promotes GSDME-mediated pyroptosis through RIPK1/FADD/caspase-8 complex formation during mitotic arrest in ovarian cancer.在卵巢癌有丝分裂停滞期间，磷酸化的IRF3通过RIPK1/FADD/半胱天冬酶-8复合物的形成促进GSDME介导的细胞焦亡。
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Steroidal saponins PPI/CCRIS/PSV induce cell death in pancreatic cancer cell through GSDME-dependent pyroptosis.甾体皂苷 PPI/CCRIS/PSV 通过依赖 GSDME 的细胞焦亡诱导胰腺癌细胞死亡。
Biochem Biophys Res Commun. 2023 Sep 17;673:51-58. doi: 10.1016/j.bbrc.2023.06.062. Epub 2023 Jun 19.
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KIF23 inhibition protects against perioperative neurocognitive disorders by hindering ROS/caspase-3/GSDME-mediated pyroptosis.KIF23抑制通过阻碍ROS/半胱天冬酶-3/GSDME介导的细胞焦亡来预防围手术期神经认知障碍。
Exp Neurol. 2025 Nov;393:115371. doi: 10.1016/j.expneurol.2025.115371. Epub 2025 Jul 8.
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Pyroptosis-Inducing Platinum(IV) Prodrugs via GSDME Pathway for Chemoimmunotherapy and Metastasis Inhibition in Triple-Negative Breast Cancer.通过GSDME途径诱导细胞焦亡的铂（IV）前药用于三阴性乳腺癌的化学免疫治疗和转移抑制
Adv Sci (Weinh). 2025 May 28:e05567. doi: 10.1002/advs.202505567.
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Pyroptosis Mediated by ROS/Caspase-3/GSDME Pathway in Aspergillus fumigatus-Induced Fungal Keratitis.活性氧/半胱天冬酶-3/ Gasdermin E途径介导的焦亡在烟曲霉诱导的真菌性角膜炎中的作用
Invest Ophthalmol Vis Sci. 2025 Jun 2;66(6):52. doi: 10.1167/iovs.66.6.52.

本文引用的文献

1
Preclinical IL2RG gene therapy using autologous hematopoietic stem cells as an effective and safe treatment for X-linked severe combined immunodeficiency disease.使用自体造血干细胞的临床前白细胞介素2受体γ链基因疗法作为X连锁重症联合免疫缺陷病的一种有效且安全的治疗方法。
Genes Dis. 2024 Nov 6;12(3):101445. doi: 10.1016/j.gendis.2024.101445. eCollection 2025 May.
2
Targeting GSDME-mediated macrophage polarization for enhanced antitumor immunity in hepatocellular carcinoma.靶向 GSDME 介导的巨噬细胞极化增强肝癌的抗肿瘤免疫。
Cell Mol Immunol. 2024 Dec;21(12):1505-1521. doi: 10.1038/s41423-024-01231-0. Epub 2024 Nov 4.
3
Full-length GSDME mediates pyroptosis independent from cleavage.
全长 GSDME 通过非切割方式介导细胞焦亡。
Nat Cell Biol. 2024 Sep;26(9):1545-1557. doi: 10.1038/s41556-024-01463-2. Epub 2024 Jul 12.
4
Triclosan inhibits testosterone biosynthesis in adult rats via inducing m6A methylation-mediated autophagy.三氯生通过诱导 m6A 甲基化介导的自噬抑制成年大鼠的睾丸酮生物合成。
Environ Int. 2024 Aug;190:108827. doi: 10.1016/j.envint.2024.108827. Epub 2024 Jun 18.
5
Artemisinins ameliorate polycystic ovarian syndrome by mediating LONP1-CYP11A1 interaction.青蒿素通过调节 LONP1-CYP11A1 相互作用改善多囊卵巢综合征。
Science. 2024 Jun 14;384(6701):eadk5382. doi: 10.1126/science.adk5382.
6
Disturbed Follicular Microenvironment in Polycystic Ovary Syndrome: Relationship to Oocyte Quality and Infertility.多囊卵巢综合征中滤泡微环境的紊乱：与卵母细胞质量和不孕的关系。
Endocrinology. 2024 Feb 20;165(4). doi: 10.1210/endocr/bqae023.
7
Hormonal changes in PCOS.多囊卵巢综合征的激素变化。
J Endocrinol. 2024 Feb 15;261(1). doi: 10.1530/JOE-23-0342. Print 2024 Apr 1.
8
Gasdermin E dictates inflammatory responses by controlling the mode of neutrophil death.Gasdermin E 通过控制中性粒细胞死亡的方式来决定炎症反应。
Nat Commun. 2024 Jan 9;15(1):386. doi: 10.1038/s41467-023-44669-y.
9
Polycystic Ovary Syndrome Fuels Cardiovascular Inflammation and Aggravates Ischemic Cardiac Injury.多囊卵巢综合征会引发心血管炎症，并加重缺血性心脏损伤。
Circulation. 2023 Dec 12;148(24):1958-1973. doi: 10.1161/CIRCULATIONAHA.123.065827. Epub 2023 Nov 8.
10
The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases.NLRP3 炎性小体与细胞焦亡在心血管疾病中的作用。
Nat Rev Cardiol. 2024 Apr;21(4):219-237. doi: 10.1038/s41569-023-00946-3. Epub 2023 Nov 3.