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诺米林通过调节脂肪细胞衍生的外泌体miRNA改善肥胖小鼠的肝脏脂质代谢。

Nobiletin Modulates Adipocyte-Derived Exosomal miRNA to Improve Liver Lipid Metabolism in Obese Mice.

作者信息

Leung Siu-Yi, Ho Nga-Ying, Ho Chi-Tang, Pan Min-Hsiung

机构信息

Institute of Food Science and Technology, National Taiwan University, Taipei 10617, Taiwan.

Department of Food Science, Rutgers University, New Brunswick, New Jersey 08901, United States.

出版信息

J Agric Food Chem. 2025 Sep 3;73(35):21959-21975. doi: 10.1021/acs.jafc.5c06392. Epub 2025 Aug 19.

DOI:10.1021/acs.jafc.5c06392
PMID:40831213
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12412145/
Abstract

This study examines the antiobesity properties of nobiletin through its influence on extracellular vesicles, particularly exosomes. Nob-ELVs (nobiletin with adipocyte-derived extracellular vesicles) significantly reduce fat accumulation in adipocytes without compromising cell viability. studies showed that introducing Nob-ELVs to 3T3-L1 preadipocytes led to marked reductions in fat accumulation. RNA sequencing indicated that Nobiletin alters the exosomal miRNA profile, downregulating miR-802-5p and others while upregulating miR-574-5p and related miRNAs. In a high-fat diet mouse model, Nob-ELVs prevented significant weight gain and improved food conversion efficiency. Mice receiving Nob-ELVs exhibited reduced hepatic lipid droplet accumulation and altered protein expressions, enhancing SIRT1 and FGF21 while suppressing ACC, FASN, and CD36. These findings suggest that Nob-ELVs inhibit fat accumulation and enhance lipid metabolism by modulating exosomal miRNAs, offering insights for new obesity treatment strategies.

摘要

本研究通过考察橙皮素对细胞外囊泡尤其是外泌体的影响，探究其抗肥胖特性。Nob-ELVs（橙皮素与脂肪细胞来源的细胞外囊泡）可显著减少脂肪细胞中的脂肪积累，且不影响细胞活力。研究表明，将Nob-ELVs引入3T3-L1前脂肪细胞可显著减少脂肪积累。RNA测序表明，橙皮素改变了外泌体miRNA谱，下调了miR-802-5p等，同时上调了miR-574-5p及相关miRNA。在高脂饮食小鼠模型中，Nob-ELVs可防止体重显著增加，并提高食物转化效率。接受Nob-ELVs的小鼠肝脏脂质滴积累减少，蛋白质表达改变，增强了SIRT1和FGF21，同时抑制了ACC、FASN和CD36。这些发现表明，Nob-ELVs通过调节外泌体miRNA抑制脂肪积累并增强脂质代谢，为新的肥胖治疗策略提供了思路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f84/12412145/35f15c4529eb/jf5c06392_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f84/12412145/2c752b4c7e13/jf5c06392_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f84/12412145/f2d0a32d5037/jf5c06392_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f84/12412145/551e0c71d01e/jf5c06392_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f84/12412145/c5d0516426bf/jf5c06392_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f84/12412145/df695b59f08d/jf5c06392_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f84/12412145/4a9e287f68bc/jf5c06392_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f84/12412145/a7025bb66004/jf5c06392_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f84/12412145/f604643a5114/jf5c06392_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f84/12412145/35f15c4529eb/jf5c06392_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f84/12412145/2c752b4c7e13/jf5c06392_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f84/12412145/f2d0a32d5037/jf5c06392_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f84/12412145/551e0c71d01e/jf5c06392_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f84/12412145/c5d0516426bf/jf5c06392_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f84/12412145/df695b59f08d/jf5c06392_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f84/12412145/4a9e287f68bc/jf5c06392_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f84/12412145/a7025bb66004/jf5c06392_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f84/12412145/f604643a5114/jf5c06392_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f84/12412145/35f15c4529eb/jf5c06392_0009.jpg

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本文引用的文献

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Biochem Soc Trans. 2025 Mar 26;0(0):BST20240523. doi: 10.1042/BST20240523.
2
Adipose tissue macrophages-derived exosomal MiR-500a-5p under high glucose promotes adipocytes inflammation by suppressing Nrf2 expression.高糖条件下脂肪组织巨噬细胞来源的外泌体MiR-500a-5p通过抑制Nrf2表达促进脂肪细胞炎症。
Int J Biochem Cell Biol. 2025 Jan;178:106713. doi: 10.1016/j.biocel.2024.106713. Epub 2024 Nov 29.
3
[Research progress in the regulation of functional homeostasis of adipose tissue by exosomal miRNA].
外泌体微小RNA对脂肪组织功能稳态调控的研究进展
Sheng Li Xue Bao. 2024 Oct 25;76(5):791-800.
4
MicroRNAs as Epigenetic Regulators of Obesity.微小 RNA 作为肥胖的表观遗传调控因子。
Adv Exp Med Biol. 2024;1460:595-627. doi: 10.1007/978-3-031-63657-8_20.
5
MicroRNA Profile of Mouse Adipocyte-Derived Extracellular Vesicles.小鼠脂肪细胞衍生细胞外囊泡的 microRNA 谱。
Cells. 2024 Aug 1;13(15):1298. doi: 10.3390/cells13151298.
6
Nobiletin regulates intracellular Ca levels via IPR and ameliorates neuroinflammation in Aβ42-induced astrocytes.川陈皮素通过 IPR 调节细胞内 Ca 水平，并改善 Aβ42 诱导的星形胶质细胞中的神经炎症。
Redox Biol. 2024 Jul;73:103197. doi: 10.1016/j.redox.2024.103197. Epub 2024 May 16.
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Recent progress in promoting the bioavailability of polyphenols in plant-based foods.提高植物性食物中多酚生物利用度的最新进展。
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