Guo Yiwen, Liu Xulin, Nicholas Stephen, Maitland Elizabeth, Liu Rugang
School of Health Policy & Management, Nanjing Medical University, Nanjing, 211166, People's Republic of China.
Health Services Research and Workforce Innovation Centre, Newcastle Business School, University of Newcastle, Newcastle, NSW, Australia.
Risk Manag Healthc Policy. 2025 Aug 14;18:2675-2689. doi: 10.2147/RMHP.S524223. eCollection 2025.
Human papillomavirus (HPV) infection and the resulting penile, anal, oropharyngeal and cervical cancer impact the health and welfare of men and women. The HPV vaccine has emerged as the most effective method to combat HPV. This study comprehensively analyzes the key influencing factors of global HPV vaccination behavior.
This systematic review synthesizes evidence on global HPV vaccination behaviors and determinants. We searched three major databases PubMed, Web of Science and Scopus for peer-reviewed literature published between 2018 and 2023. Studies from diverse geographical regions and population subgroups were analyzed using thematic synthesis and narrative approaches.
In the published literature, men and men who have sex with men (MSM) were under-represented groups. Both subjective and objective determinants influenced HPV vaccination behavior, including parental attitudes, knowledge of health professionals and gendered views about HPV risks. In the studies reviewed, HPV vaccination rates were low globally, with few countries achieving vaccination rates above 70%.
Key HPV vaccination determinants included education level, parental attitudes, knowledge and awareness of HPV and its vaccine and acceptance of the HPV vaccine. Based on the literature survey, we provide recommendations for governments and health institutions to improve gender-specific HPV vaccination rates, including MSM.
人乳头瘤病毒（HPV）感染以及由此引发的阴茎癌、肛门癌、口咽癌和宫颈癌影响着男性和女性的健康与福祉。HPV疫苗已成为对抗HPV的最有效方法。本研究全面分析了全球HPV疫苗接种行为的关键影响因素。
本系统评价综合了关于全球HPV疫苗接种行为及其决定因素的证据。我们在三个主要数据库（PubMed、科学网和Scopus）中检索了2018年至2023年期间发表的同行评审文献。使用主题综合和叙述方法对来自不同地理区域和人群亚组的研究进行了分析。
在已发表的文献中，男性和男男性行为者（MSM）是代表性不足的群体。主观和客观决定因素均影响HPV疫苗接种行为，包括父母的态度、卫生专业人员的知识以及对HPV风险的性别化看法。在所审查的研究中，全球HPV疫苗接种率较低，很少有国家的接种率超过70%。
HPV疫苗接种的关键决定因素包括教育水平、父母态度、对HPV及其疫苗的知识和认识以及对HPV疫苗的接受程度。基于文献调查，我们为政府和卫生机构提供了提高特定性别人群（包括男男性行为者）HPV疫苗接种率的建议。
