Su Wenqiang, Gu Haorong, Zheng Jun, Jia Honglin
State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences (CAAS), Harbin, China.
Front Cell Infect Microbiol. 2025 Aug 4;15:1642716. doi: 10.3389/fcimb.2025.1642716. eCollection 2025.
is an obligate intracellular apicomplexan parasite. Most apicomplexan parasites contain an endosymbiont-derived organelle called the apicoplast. This organelle is critical for the survival of parasites because it plays a role in several essential metabolic pathways. However, the molecular mechanisms involved in maintaining the apicoplast have not been well understood. In this study, we investigated the function of an apicoplast-residing protein called YCAP in the inheritance of the apicoplast. Our results showed that conditional knockdown of YCAP severely inhibited the growth of the parasite and disrupted the inheritance of the apicoplast. In addition, the YGGT domain is essential for its function in the apicoplast.
是一种专性细胞内顶复门寄生虫。大多数顶复门寄生虫含有一种称为质体的内共生起源细胞器。这种细胞器对寄生虫的生存至关重要，因为它在几个重要的代谢途径中发挥作用。然而，维持质体的分子机制尚未得到很好的理解。在本研究中，我们研究了一种存在于质体中的蛋白质YCAP在质体遗传中的功能。我们的结果表明，条件性敲低YCAP严重抑制了寄生虫的生长，并破坏了质体的遗传。此外，YGGT结构域对其在质体中的功能至关重要。
