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[转移性脊柱病变的放射治疗进展]

[Advances in Radiotherapy in the Treatment of Metastatic Spinal Lesions].

作者信息

Coimbra Brian Guilherme Monteiro Marta, Silva Alice Roxo Nobre de Souza E, Soares Cauã Bhering, Figueiredo Caio César Nogueira de, Macamo Manuel Salvado, Cristante Alexandre Fogaça

机构信息

Grupo de Coluna, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brasil.

Grupo de Radioterapia, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brasil.

出版信息

Rev Bras Ortop (Sao Paulo). 2025 Aug 18;60(3):1-7. doi: 10.1055/s-0045-1810031. eCollection 2025 Jun.

Abstract

Metastatic spinal disease has become increasingly common due to advances in systemic oncological therapies and the increase in the overall survival of cancer patients. Its treatment is palliative, but the meaning of this term has evolved and, today, consists of better and more effective condition control over longer periods. In the past, surgical and radiotherapy techniques, especially conventional external beam radiation therapy (cEBRT), were ineffective or morbid for controlling many types of tumors. Now, the emergence and advancement of stereotactic body radiation therapy (SBRT) drastically changed this scenario. Surgery for managing metastatic disease remains significant in radiotherapy-associated strategies, but its purpose and technique have undergone major updates. However, despite all technical advances, radiotherapy has toxicity and side effects that warrant consideration. In this article, we provide an updated review covering everything from history to innovations in treating spinal metastases, focusing on their benefits, indications, and clinical impact.

摘要

由于全身肿瘤治疗的进展以及癌症患者总体生存率的提高,转移性脊柱疾病变得越来越常见。其治疗是姑息性的,但这个术语的含义已经演变,如今包括在更长时间内更好、更有效地控制病情。过去,手术和放疗技术,尤其是传统的外照射放疗(cEBRT),在控制多种类型肿瘤方面效果不佳或存在严重问题。现在,立体定向体部放疗(SBRT)的出现和发展彻底改变了这种局面。在与放疗相关的策略中,手术治疗转移性疾病仍然具有重要意义,但其目的和技术已经有了重大更新。然而,尽管有所有这些技术进步,放疗仍有需要考虑的毒性和副作用。在本文中,我们提供了一篇最新综述,涵盖从脊柱转移瘤治疗的历史到创新的所有内容,重点关注其益处、适应症和临床影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c85e/12360859/4c6fdcf40b56/10-1055-s-0045-1810031-i2500029pt-1.jpg

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