Kim Hye Jun, Park Sun Jae, Oh Yun Hwan, Jeong Seogsong, Park Sang Min
Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.
Department of Family Medicine, Chung-Ang University Gwangmyeong Hospital, Chung-Ang University College of Medicine, Gwangmyeong, South Korea.
Prev Med Rep. 2025 Aug 8;57:103200. doi: 10.1016/j.pmedr.2025.103200. eCollection 2025 Sep.
While physical activity is known to influence atrial fibrillation risk in the general population, evidence is limited among patients newly diagnosed with dyslipidemia. This study aimed to evaluate the association between changes in physical activity before and after dyslipidemia diagnosis and atrial fibrillation risk.
Using the Korean National Health Insurance Service database, we identified 441,509 Korean adults newly diagnosed with dyslipidemia between 2011 and 2015, free of atrial fibrillation at baseline and with complete data. Metabolic equivalent tasks (METs)-min/week were calculated before and after dyslipidemia diagnosis. Participants were followed up until atrial fibrillation, death, or December 31, 2021.
During 3,164,996 person-years of follow-up, 6003 patients developed atrial fibrillation. Increasing physical activity from inactive to ≥1000 MET-min/week was associated with reduced atrial fibrillation risk (adjusted hazard ratio [aHR], 0.85; 95 % confidence interval [CI], 0.81-0.90), compared with inactive. Conversely, decreasing physical activity from ≥1000 MET-min/week to inactive was associated with increased atrial fibrillation risk (aHR, 1.23; 95 % CI, 1.15-1.31). These results were consistent regardless of statin use, hypoalphalipoproteinemia, and hyperlipidemia status.
Encouraging newly diagnosed dyslipidemia patients to increase their physical activity levels may help reduce their risk of atrial fibrillation.
虽然已知体育活动会影响普通人群患房颤的风险，但在新诊断为血脂异常的患者中，证据有限。本研究旨在评估血脂异常诊断前后体育活动变化与房颤风险之间的关联。
利用韩国国民健康保险服务数据库，我们确定了2011年至2015年间新诊断为血脂异常的441509名韩国成年人，这些人在基线时无房颤且数据完整。计算血脂异常诊断前后的代谢当量任务（METs）-分钟/周。对参与者进行随访，直至发生房颤、死亡或2021年12月31日。
在3164996人年的随访期间，6003名患者发生了房颤。与不活动相比，将体育活动从不活动增加到≥1000 MET-分钟/周与房颤风险降低相关（调整后的风险比[aHR]，0.85；95%置信区间[CI]，0.81-0.90）。相反，将体育活动从≥1000 MET-分钟/周减少到不活动与房颤风险增加相关（aHR，1.23；95%CI，1.15-1.31）。无论是否使用他汀类药物、低α脂蛋白血症和高脂血症状态如何，这些结果都是一致的。
鼓励新诊断的血脂异常患者增加体育活动水平可能有助于降低其房颤风险。
