Rivington R N, Calcutt L, Child S, MacLeod J P, Hodder R V, Stewart J H
Am J Med. 1985 Dec 20;79(6A):67-72. doi: 10.1016/0002-9343(85)90092-0.
A double-blind, cross-over comparison of morning (8 A.M.) versus evening (10 P.M.) dosing regimens with a new once-daily oral theophylline (Uniphyl, Purdue Frederick) was performed. The comparison was based upon steady-state theophylline pharmacokinetics, spirometric measurements over 24 hours, the patients' quantitative reporting of asthmatic symptoms, and medication side effects. No statistically significant differences were observed in any theophylline parameter between the dosing regimens. Evening dosing, but not morning dosing, resulted in a significant attenuation of the early morning dip in pulmonary function. The morning severity of wheezing, chest tightness, and shortness of breath was significantly reduced after evening dosing. Overall no difference in the incidence of symptoms was noted. No significant differences in side effects were noted. Evening dosing with Uniphyl produced a significant improvement in morning pulmonary function, and this benefit was subjectively noted by the patients. No decline in this benefit was noted later in the day. Evening dosing with Uniphyl clearly is superior to morning dosing.
对一种新型每日一次口服茶碱（优喘平，普渡弗雷德里克公司）的早晨（上午8点）与晚上（晚上10点）给药方案进行了双盲交叉比较。该比较基于稳态茶碱药代动力学、24小时肺功能测定、患者对哮喘症状的定量报告以及药物副作用。在给药方案之间，任何茶碱参数均未观察到统计学上的显著差异。晚上给药可显著减轻肺功能的清晨下降，但早晨给药则无此效果。晚上给药后，喘息、胸闷和呼吸急促的早晨严重程度显著降低。总体而言，症状发生率无差异。副作用方面未观察到显著差异。优喘平晚上给药可显著改善早晨肺功能，患者主观上也注意到了这一益处。当天晚些时候未发现这种益处有所下降。优喘平晚上给药明显优于早晨给药。
