在固相上组装核酸树枝状分子的新方法。
New Approach to Assembling Nucleic Acid Dendrons on a Solid Phase.
作者信息
Chik Gerald J, El-Sagheer Afaf H, Brown Tom
机构信息
Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, United Kingdom.
School of Chemistry and Chemical Engineering, University of Southampton, Highfield, Southampton SO17 1BJ, United Kingdom.
出版信息
Org Lett. 2025 Aug 29;27(34):9500-9505. doi: 10.1021/acs.orglett.5c02877. Epub 2025 Aug 20.
We report the methodology to synthesize nucleic acid dendrons on a solid support via Cu(I)-catalyzed alkyne-azide cycloaddition (CuAAC). Current methods require excess coupling reagents and result in low yields. Our alternative strategy is based on standard solid-phase synthesis followed by 5'-end coupling of a multifunction linker to efficiently afford dendrons. This approach enables the synthesis of DNA/RNA dendrons whose properties are compatible with therapeutic applications.
我们报告了一种通过铜（I）催化的炔烃-叠氮化物环加成反应（CuAAC）在固体支持物上合成核酸树枝状分子的方法。目前的方法需要过量的偶联试剂，产率较低。我们的替代策略基于标准的固相合成，随后通过多功能连接子的5'-末端偶联来高效地制备树枝状分子。这种方法能够合成其性质与治疗应用兼容的DNA/RNA树枝状分子。
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