Omar Shaimaa I, Al-Jarem Yehia Farouk, El Banaa Alshaimaa Mohamed, Essawy Marwa
Shaimaa I. Omar, MBBCh, MD, is Associate Professor; Yehia Farouk Al-Jarem, MD, is Professor; Alshaimaa Mohamed El Banaa, MS, is Resident, Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University, Egypt. Marwa Essawy, MD, is Associate Professor, Oral Pathology Department, Faculty of Dentistry, Alexandria University, Egypt and is also at Center of Excellence for Research in Regenerative Medicine and Applications (CERRMA), Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Adv Skin Wound Care. 2025 Sep 1;38(8):E41-E49. doi: 10.1097/ASW.0000000000000326. Epub 2025 Aug 14.
To investigate and compare the effectiveness and safety of pulsed dye laser (PDL), topical brimonidine tartrate, and their combined use in post-acne erythema (PAE) treatment.
In this randomized clinical comparative trial, 60 patients who had PAE on both sides of the face were equally divided into 2 groups. According to a split-face design, the PAE lesions in each participant of group A were randomly treated with PDL followed by brimonidine tartrate on one side and PDL alone on the other one. Alternatively, PAE lesions on each face side in group B were treated with a single-treatment modality, either brimonidine or PDL. The efficiency of treatments was assessed by the Global Assessment of Improvement scores, by the clinical assessment of PAE lesion count, and patient satisfaction, as well as objective morphometric analysis of the patient photographs.
Significant improvement was noticed subjectively and objectively after treatment with PDL alone, brimonidine alone, and PDL+brimonidine compared with baseline. In group A, PDL+brimonidine achieved superior improvement with regard to global assessment of improvement, percentage of lesion count reduced, erythema index, and patient satisfaction.
Pulsed dye laser and topical brimonidine separately proved to be effective and safe in the treatment of PAE. Their combination can have an additively positive therapeutic outcome.
探讨并比较脉冲染料激光（PDL）、外用酒石酸溴莫尼定及其联合应用治疗痤疮后红斑（PAE）的有效性和安全性。
在这项随机临床对照试验中，60例面部两侧均有PAE的患者被平均分为2组。根据半脸设计，A组的每位参与者一侧的PAE皮损先用PDL治疗，然后外用酒石酸溴莫尼定，另一侧仅用PDL治疗。或者，B组每侧面部的PAE皮损采用单一治疗方式，即使用酒石酸溴莫尼定或PDL。通过整体改善评估评分、PAE皮损计数的临床评估、患者满意度以及对患者照片进行客观形态学分析来评估治疗效果。
与基线相比，单独使用PDL、单独使用酒石酸溴莫尼定以及PDL + 酒石酸溴莫尼定治疗后，主观和客观上均有显著改善。在A组中，PDL + 酒石酸溴莫尼定在整体改善评估、皮损计数减少百分比、红斑指数和患者满意度方面取得了更好的改善效果。
脉冲染料激光和外用酒石酸溴莫尼定分别被证明在治疗PAE方面是有效且安全的。它们的联合使用可产生相加的积极治疗效果。
