Harada Ryo, Bao Mingxue, Okabe Natsuki, Kasai Yuka, Takahashi Airi, Kuleshov Chio, Shigemoto Yumi, Ooka Tadao, Yokomichi Hiroshi, Miyake Kunio, Kojima Reiji, Shinohara Ryoji, Yui Hideki, Otawa Sanae, Kushima Megumi, Yamagata Zentaro, Kashiwagi Kenji
Department of Ophthalmology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan.
Department of Ophthalmology, Kofu Kyoritsu Clinic, Yamanashi, Japan.
PLoS One. 2025 Aug 20;20(8):e0330335. doi: 10.1371/journal.pone.0330335. eCollection 2025.
The purpose of this study was to investigate the relationships between the circumpapillary retinal nerve fiber layer thickness (cpRNFL) and optic disc parameters and associated factors in 8-year-old Japanese children who participated in the Yamanashi Adjunct Study of the Japan Environment and Children's Study (JECS).
The participants in this study were 559 8-year-old Japanese children (277 boys and 282 girls) who participated in the Yamanashi Adjunct Study of JECS at the University of Yamanashi from June 2021 to March 2022. The visual acuity, spherical equivalent (SE), and axial length (AL) of the participants were measured. The cpRNFL thickness was measured with a spectral domain optical coherence tomograph (NIDEK RS-3000 Advance, Gamagori, Japan).
The data of 349 participants (182 boys and 167 girls) were ultimately analyzed. Multivariable analysis showed that AL was significantly positively correlated with the cpRNFL thickness in the 8 o'clock sector (β = 0.26; 95% confidence interval (CI) 2.74-6.87) and significantly negatively correlated with the cpRNFL thickness in the 6 o'clock sector (β = -0.21; 95%CI -9.94--2.98). The cpRNFL thickness in the 10 o'clock and 11 o'clock sectors was greater for girls than for boys (β = 0.21; 95%CI 2.54-8.34; and β = 0.15; 95%CI 1.85-11.99, respectively), whereas in the 12 o'clock sector, it was greater for boys (β = -0.26; 95%CI -20.41--8.32). The disc area was significantly positively correlated with the cpRNFL thickness in the 7 o'clock, 10 o'clock and 11 o'clock sectors (β = 0.13, 95%CI 0.93-8.67; β = 0.13, 95%CI 10.36-23.88; and β = 0.27, 95%CI 10.36-23.88, respectively).
The thickness of the cpRNFL in 8-year-old Japanese children was associated with AL, sex, and disc area, but these associations differed by RNFL sector.
本研究旨在调查参与日本环境与儿童研究（JECS）山梨附属研究的8岁日本儿童的视乳头周围视网膜神经纤维层厚度（cpRNFL）与视盘参数及相关因素之间的关系。
本研究的参与者为2021年6月至2022年3月在山梨大学参加JECS山梨附属研究的559名8岁日本儿童（277名男孩和282名女孩）。测量了参与者的视力、等效球镜度（SE）和眼轴长度（AL）。使用光谱域光学相干断层扫描仪（日本蒲郡NIDEK RS - 3000 Advance）测量cpRNFL厚度。
最终分析了349名参与者（182名男孩和167名女孩）的数据。多变量分析显示，AL与8点方位的cpRNFL厚度显著正相关（β = 0.26；95%置信区间（CI）2.74 - 6.87），与6点方位的cpRNFL厚度显著负相关（β = -0.21；95%CI -9.94 - -2.98）。女孩在10点和11点方位的cpRNFL厚度大于男孩（β分别为0.21；95%CI 2.54 - 8.34和β为0.15；95%CI 1.85 - 11.99），而在12点方位，男孩的cpRNFL厚度更大（β = -0.26；95%CI -20.41 - -8.32）。视盘面积与7点、10点和11点方位的cpRNFL厚度显著正相关（β分别为0.13，95%CI 0.93 - 8.67；β为0.13，95%CI 10.36 - 23.88；β为0.27，95%CI 10.36 - 23.88）。
8岁日本儿童的cpRNFL厚度与AL、性别和视盘面积有关，但这些关联在视网膜神经纤维层不同方位存在差异。
