Gulbransen Brian D, Verkhratsky Alexei, Parpura Vladimir
Department of Physiology, Michigan State University, East Lansing, MI, USA.
Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK; Department of Neurosciences, University of the Basque Country, Leioa, Spain; IKERBASQUE Basque Foundation for Science, Bilbao, Spain; International Joint Research Centre on Purinergic Signalling of Sichuan Province Chengdu University of Traditional Chinese Medicine, Chengdu, China; Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital of Sun Yat-sen University, No. 628 Zhenyuan Road, Shenzhen, 518107, Guangdong, China; Celica, BIOMEDICAL, Technology Park 24, 1000, Ljubljana, Slovenia; Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang, China.
Neuropharmacology. 2025 Nov 15;279:110645. doi: 10.1016/j.neuropharm.2025.110645. Epub 2025 Aug 18.
We celebrate the life of our colleague Francesco Di Virgilio, who in his very last public lecture discussed purinergic signaling in neuroglia in physiology and pathophysiology. Here, we write on a subset of a unique type of peripheral neuroglia, enteric glia that accompany enteric neurons in the enteric nervous system of the gut and act to maintain homeostasis in enteric neurocircuits. Bi-directional communication between enteric neurons and glia is majorly mediated by purines. Enteric glia also play central roles in regulating the availability of extracellular purines in enteric circuits. Changes in glial purinergic signaling and control mechanisms contribute to neuroplasticity and disease susceptibility in inflammatory contexts. This review summarizes the current state of the field in understanding how enteric glia are involved in purinergic signaling in the enteric nervous system.
我们缅怀同事弗朗切斯科·迪·维尔吉利奥的一生，在他最后一次公开讲座中，探讨了神经胶质细胞中嘌呤能信号在生理和病理生理中的作用。在此，我们论述一种独特类型的外周神经胶质细胞的一个子集，即肠神经胶质细胞，它伴随肠道肠神经系统中的肠神经元，并在维持肠神经回路的内环境稳定中发挥作用。肠神经元与神经胶质细胞之间的双向通讯主要由嘌呤介导。肠神经胶质细胞在调节肠回路中细胞外嘌呤的可用性方面也起着核心作用。在炎症环境中，神经胶质细胞嘌呤能信号和控制机制的变化会导致神经可塑性和疾病易感性。本综述总结了该领域目前对于肠神经胶质细胞如何参与肠神经系统中嘌呤能信号传导的理解现状。
