Ellis Jamie, Galea Mary P, Scheinberg Adam, Simm Peter
Murdoch Children's Research Institute, Parkville, VIC, Australia.
Department of Medicine (Royal Melbourne Hospital), The University of Melbourne, Parkville, VIC, Australia.
Spinal Cord Ser Cases. 2025 Aug 20;11(1):24. doi: 10.1038/s41394-025-00720-2.
Cross-sectional study OBJECTIVES: Spinal cord disorders (SCD) in children are uncommon, but for those affected the musculoskeletal effects can be severe. Little is known about bone health and pediatric SCD experiences in Australia. We aimed to describe bone and muscle development following pediatric SCD.
The Royal Children's Hospital, Melbourne, Australia METHODS: Ten participants with SCD were recruited and underwent peripheral quantitative computed tomography (pQCT) scans and blood tests to observe bone health biochemistry.
Z-scores (mean ± SD) for trabecular density at the 4% tibial site were lower in non-weightbearing children compared to weightbearing children (-6.5 ± 1.5 vs. -2.4 ± 1.5, Total cohort: -5.0 ± 2.6). At the 66% site, muscle cross-sectional area (-4.7 ± 2.2 vs. -1.1 ± 1.7, Total cohort: -3.1 ± 2.7), strength strain index (-3.4 ± 1.3 vs. -1.0 ± 0.4, Total cohort: -2.5 ± 1.6) and total bone cross-sectional area (-2.4 ± 0.8 vs. 0.4 ± 1.7, Total cohort: -1.2 ± 1.9) were also lower in non-weightbearing children. Radial Z-scores revealed reduced total bone area at the 4% site (-3.5 ± 2.1) and strength strain index at the 65% site (-1.3 ± 1.8) in all participants. Serum testing revealed alkaline phosphatase was reduced in three participants, one of whom was also deficient in phosphate and 25-Hydroxyvitamin D.
Weightbearing status influenced multiple outcomes including trabecular density, muscle cross-sectional area and bone strength in the tibia.
横断面研究
儿童脊髓疾病（SCD）并不常见，但对于受影响的儿童，其肌肉骨骼影响可能很严重。在澳大利亚，人们对骨骼健康和小儿SCD的情况了解甚少。我们旨在描述小儿SCD后的骨骼和肌肉发育情况。
澳大利亚墨尔本皇家儿童医院
招募了10名患有SCD的参与者，进行外周定量计算机断层扫描（pQCT）和血液测试，以观察骨骼健康生化指标。
与负重儿童相比，非负重儿童胫骨4%部位的小梁密度Z值（平均值±标准差）更低（-6.5±1.5对-2.4±1.5，总队列：-5.0±2.6）。在66%部位，非负重儿童的肌肉横截面积（-4.7±2.2对-1.1±1.7，总队列：-3.1±2.7）、力量应变指数（-3.4±1.3对-1.0±0.4，总队列：-2.5±1.6）和总骨横截面积（-2.4±0.8对0.4±1.7，总队列：-1.2±1.9）也更低。桡骨Z值显示，所有参与者在4%部位的总骨面积减少（-3.5±2.1），在65%部位的力量应变指数降低（-1.3±1.8）。血清检测显示，三名参与者的碱性磷酸酶降低，其中一人还缺乏磷酸盐和25-羟基维生素D。
负重状态影响多个结果，包括胫骨的小梁密度、肌肉横截面积和骨强度。
