Semrad S D, Hardee G E, Hardee M M, Moore J N
Am J Vet Res. 1985 Dec;46(12):2474-9.
The pharmacokinetics and inhibition of prostaglandin synthesis in conscious horses given various dosages of flunixin meglumine were studied. Plasma concentrations of flunixin were measured by high-performance liquid chromatography, and serum thromboxane B2 and 6-keto prostaglandin F1 alpha were quantitated by radioimmunoassay. Within the dosage range studied, linear pharmacokinetics were achieved. After IV administration of flunixin (1.1 mg/kg, 0.25 mg/kg, 0.1 mg/kg), significant suppression of serum thromboxane generation persisted for 12, 4, and 3 hours, respectively. Repeated administrations of flunixin (0.25 mg/kg) once every 8 hours maintained significant suppression of thromboxane generation for the duration of treatment. After treatment with flunixin was stopped, serum thromboxane generation exceeded base line (pretreatment values). Among the groups, significant alteration of 6-keto prostaglandin F1 alpha production was not observed.
研究了给清醒马匹给予不同剂量氟尼辛葡甲胺后的药代动力学及对前列腺素合成的抑制作用。采用高效液相色谱法测定氟尼辛的血浆浓度，并用放射免疫分析法对血清血栓素B2和6-酮前列腺素F1α进行定量。在所研究的剂量范围内，呈现线性药代动力学。静脉注射氟尼辛（1.1毫克/千克、0.25毫克/千克、0.1毫克/千克）后，血清血栓素生成的显著抑制分别持续12小时、4小时和3小时。每8小时重复给予氟尼辛（0.25毫克/千克），在治疗期间维持对血栓素生成的显著抑制。停止使用氟尼辛治疗后，血清血栓素生成超过基线（治疗前值）。各实验组之间，未观察到6-酮前列腺素F1α生成的显著改变。
