Stover S M, Pool R R
Am J Vet Res. 1985 Dec;46(12):2485-91.
Gentamicin sulfate (3 ml; 50 mg/ml) was administered intra-articularly into 30 normal equine radiocarpal joints after arthrocentesis. Arthrocentesis alone was performed on 10 normal radiocarpal joints. Synovial fluid evaluations and gross and microscopic examinations were performed on synovial fluid and synovial membrane of designated joints at selected daily intervals over a period of 10 days. Synovial fluid from gentamicin-injected joints had greater turbidity, higher RBC and WBC counts, and higher refractive indices than did joints not injected with gentamicin. The largest increases developed on days 1 or 2 after gentamicin injection, with mean total WBC, large mononuclear cell, small mononuclear cell, and polymorphonuclear cell counts of 23,860, 11,853, 857, and 11,150 cells/microliter, respectively. Arthrocentesis alone resulted in smaller increases in these counts. Microscopic changes seen in the synovial membrane of gentamicin-injected joints included edema, leukocytic infiltration, and loss of synovial lining cells. These inflammatory changes resolved within 7 days after gentamicin injection.
在关节穿刺后，将硫酸庆大霉素（3毫升；50毫克/毫升）关节内注射到30个正常马的桡腕关节中。对10个正常桡腕关节仅进行关节穿刺。在10天的时间内，按选定的每日间隔对指定关节的滑液和滑膜进行滑液评估以及大体和显微镜检查。与未注射庆大霉素的关节相比，注射庆大霉素关节的滑液浊度更高、红细胞和白细胞计数更高、折射率更高。注射庆大霉素后第1天或第2天出现最大增幅，平均白细胞总数、大单核细胞、小单核细胞和多形核细胞计数分别为23,860、11,853、857和11,150个细胞/微升。仅进行关节穿刺导致这些计数的增幅较小。在注射庆大霉素关节的滑膜中观察到的微观变化包括水肿、白细胞浸润和滑膜衬里细胞丧失。这些炎症变化在注射庆大霉素后7天内消退。
