Burrows C F, Bright R M, Spencer C P
Am J Vet Res. 1985 Dec;46(12):2609-12.
Gastric dilatation-volvulus is a dramatic and life-threatening disease of large-breed dogs. The cause is unknown, but ingestion of dry cereal-based food is frequently incriminated as a predisposing factor. The purpose of this study was to examine the effect of commercial diets on gastric motility and emptying in the dog. Four large-breed dogs were fed 3 different diets (diet A = canned meat-based; B = cereal-based with 77% added water; and C = dry cereal-based) in a randomized block design. Each experiment was done in triplicate. Motility was assessed, using 5 AgAgCl electrodes and 2 strain gauges sutured along the serosa of the stomach and proximal duodenum. Dogs were fed at the same time each day and the time to change from the fed to the fasted pattern of gastrointestinal motility (changeover) was measured. Gastric emptying was assessed by recording gastric radioactivity. After feeding a meal mixed with 99mTc-labeled resin, the log of activity was plotted against time, and the half-time of gastric emptying (t1/2 GE) was calculated. Mean (+/- SEM) times from feeding to changeover for the 3 diets were: diet A, 9.7 +/- 0.9; B, 10.5 +/- 0.4; and C, 11.0 +/- 0.8 hours. Diet had minimal influence on the half time of gastric emptying (diet A, 2.2 +/- 0.3; B, 2.6 +/- 0.4; and C, 2.9 +/- 0.3 hours; P greater than 0.05). The data indicate that gastric motility and emptying in healthy large-breed dogs were not affected by dietary composition. Because most large dogs are fed cereal-based food for reasons of cost and ease of use, these diets may have been wrongly incriminated as a predisposing factor in gastric dilatation-volvulus.
胃扩张-扭转是大型犬类中一种严重且危及生命的疾病。病因不明，但常认为食用以谷物为基础的干粮是一个诱发因素。本研究的目的是检验商业犬粮对犬胃动力和排空的影响。采用随机区组设计，给4只大型犬喂食3种不同的犬粮（犬粮A = 以肉类为基础的罐头食品；B = 含77%额外水分的谷物类犬粮；C = 以谷物为基础的干粮）。每个实验重复3次。使用5个银-氯化银电极和2个应变片沿胃和十二指肠近端的浆膜缝合来评估胃动力。每天在同一时间给犬喂食，并测量从进食状态转变为空腹状态的胃肠动力变化时间（转换时间）。通过记录胃放射性来评估胃排空情况。喂食与99mTc标记树脂混合的食物后，绘制放射性对数与时间的关系图，并计算胃排空半衰期（t1/2 GE）。3种犬粮从喂食到转换的平均（±标准误）时间分别为：犬粮A，9.7±0.9小时；B，10.5±0.4小时；C，11.0±0.8小时。犬粮对胃排空半衰期影响极小（犬粮A，2.2±0.3小时；B，2.6±0.4小时；C，2.9±0.3小时；P>0.05）。数据表明，健康大型犬的胃动力和排空不受饮食成分影响。由于大多数大型犬因成本和使用方便而喂食以谷物为基础的食物，这些犬粮可能被错误地认定为胃扩张-扭转的诱发因素。
