Raccuglia Davide, Suárez-Grimalt Raquel, Krumm Laura, Ender Anatoli, Brodersen Cédric B, Jagannathan Sridhar R, Freire Krück Martin, Pampaloni Niccolò P, Rauch Carolin, Winter York, Yvon-Durocher Genevieve, Kempter Richard, Geiger Jörg R P, Owald David
Institute of Neurophysiology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Einstein Center for Neurosciences Berlin, Berlin, Germany.
Nature. 2025 Aug 20. doi: 10.1038/s41586-025-09376-2.
Animals require undisturbed periods of rest during which they undergo recuperative processes. However, it is unclear how brain states arise that are able to dissociate an animal from its external world, enabling quiescent behaviours, while retaining vigilance to salient sensory cues. Here we describe a neural mechanism in Drosophila that creates neural filters that engender a brain state that enables quiescent behaviour by generating coherent slow-wave activity (SWA) between sleep-need (R5)- and locomotion-promoting neural networks. The coherence of SWA is subject to circadian and homeostatic control and can be modulated by sensory experience. Mimicry of coherent SWA reveals that R5 oscillations reduce responsiveness to visual stimuli by rhythmically associating neural activity of locomotion-promoting cells, effectively overruling their output. These networks can regulate behavioural responsiveness by providing antagonistic inputs to downstream head-direction cells. Thus, coherent oscillations provide the mechanistic basis for a neural filter by temporally associating opposing signals, resulting in reduced functional connectivity between locomotion-gating and navigational networks. We propose that the temporal pattern of SWA provides the structure to create a 'breakable' filter, permitting the animal to enter a quiescent state, while providing the architecture for strong or salient stimuli to 'break' the neural interaction, consequently allowing the animal to react.
动物需要不受干扰的休息期，在此期间它们会经历恢复过程。然而，目前尚不清楚大脑状态是如何产生的，这种状态能够使动物与外部世界分离，实现静止行为，同时又能对显著的感官线索保持警觉。在这里，我们描述了果蝇中的一种神经机制，该机制创建了神经过滤器，通过在睡眠需求（R5）和促进运动的神经网络之间产生连贯的慢波活动（SWA），从而产生一种能够实现静止行为的大脑状态。SWA的连贯性受昼夜节律和稳态控制，并可由感官体验调节。模仿连贯的SWA发现，R5振荡通过有节奏地关联促进运动细胞的神经活动来降低对视觉刺激的反应性，有效地否决了它们的输出。这些网络可以通过向下游头部方向细胞提供拮抗输入来调节行为反应性。因此，连贯振荡通过在时间上关联相反信号为神经过滤器提供了机制基础，导致运动门控和导航网络之间的功能连接减少。我们提出，SWA的时间模式提供了创建“可打破”过滤器的结构，使动物能够进入静止状态，同时为强烈或显著的刺激提供“打破”神经相互作用的架构，从而使动物能够做出反应。
