Moore Lorna G
Department of Obstetrics and Gynaecology, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, USA.
Philos Trans R Soc Lond B Biol Sci. 2025 Aug 21;380(1933):20240168. doi: 10.1098/rstb.2024.0168.
Pregnancy encompasses the portion of the life cycle subjected to among the strongest of evolutionary pressures owing to the nature of mammalian reproduction and the characteristics of the human species. The pioneering work of early investigators such as Joseph Barcroft, Donald Barron, Giacomo Meschia, James Metcalfe and others laid the groundwork for identifying constraints affecting each of the three major players in mammalian reproduction-fetus, placenta and mother-for meeting the increased oxygen and other nutrient demands required for fetal growth and maternal wellbeing. The papers comprising this special issue illustrate how each player responds under the conditions of the chronic hypoxia present at high altitude, as well as under other circumstances limiting oxygen supply. Recognizing the contributions of each player and the importance of their interactions can point the way towards actionable targets for developing new therapies for improving both immediate and later-in-life outcomes for both mother and child.This article is part of the discussion meeting issue 'Pregnancy at high altitude: the challenge of hypoxia'.
由于哺乳动物繁殖的本质和人类物种的特征，怀孕是生命周期中受到最强进化压力影响的阶段。约瑟夫·巴克罗夫特、唐纳德·巴伦、贾科莫·梅西亚、詹姆斯·梅特卡夫等早期研究者的开创性工作为确定影响哺乳动物繁殖中三个主要参与者——胎儿、胎盘和母亲——的限制因素奠定了基础，以满足胎儿生长和母亲健康所需增加的氧气和其他营养需求。本期特刊中的论文阐述了每个参与者在高海拔地区存在的慢性缺氧条件下以及在其他限制氧气供应的情况下的反应。认识到每个参与者的贡献及其相互作用的重要性，可以为开发新疗法指明可采取行动的目标，以改善母婴的近期和远期健康结果。本文是“高海拔地区的怀孕：缺氧的挑战”讨论会议特刊的一部分。
