经颅细胞外阻抗控制（tEIC）的理论与实践。

Theory and practice of transcranial extracellular impedance control (tEIC).

作者信息

Matani Ayumu

机构信息

Center for Brain, Mind and KANSEI Sciences Research, Hiroshima University, Hiroshima, Hiroshima 734-8551, Japan.

出版信息

MethodsX. 2025 Aug 5;15:103552. doi: 10.1016/j.mex.2025.103552. eCollection 2025 Dec.

DOI:10.1016/j.mex.2025.103552

PMID:40837079

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12361795/

Abstract

As the working hypothesis in the present study, neural coupling (NC) is the sum of synaptic coupling (SC) and volume current coupling (VcC), and VcC influences cognitive and behavioral functions. VcC is a remote direct electrical coupling, or electrical crosstalk, across extracellular space between electroencephalogram (EEG) generators, which are spatiotemporally synchronously activated pyramidal neural populations. VcCs can occur everywhere in the brain along volume current (Vc) propagation paths. Transcranial extracellular impedance control (tEIC) can modulate the ongoing Vc distribution; therefore, tEIC can modulate VcCs and affect cognition and behavior that involve VcCs. Here, I•provide the mathematical formulations of VcC and tEIC effects•explain practical settings involved in tEIC.

摘要

作为本研究的工作假设，神经耦合（NC）是突触耦合（SC）和容积电流耦合（VcC）的总和，并且VcC影响认知和行为功能。VcC是脑电图（EEG）发生器之间跨细胞外空间的远程直接电耦合或电串扰，这些发生器是时空同步激活的锥体神经群体。VcC可沿着容积电流（Vc）传播路径在大脑中的任何部位发生。经颅细胞外阻抗控制（tEIC）可调节正在进行的Vc分布；因此，tEIC可调节VcC并影响涉及VcC的认知和行为。在此，我给出VcC和tEIC效应的数学公式，并解释tEIC所涉及的实际设置。