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与妊娠相关的获得性子宫动静脉瘘的医学治疗:2例病例报告及文献综述

Medical treatment of acquired uterine arteriovenous fistulae related to pregnancy: 2 case reports and literature review.

作者信息

Huang Lingna, Qiu Lini, Zhang Jinwen, Ye Hui, Xiong Xiumei

机构信息

Department of Gynecology and Onbstetrics, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China.

School of Basic Medicine Sciences, Fujian Medical University, Fuzhou, Fujian, China.

出版信息

Front Med (Lausanne). 2025 Aug 5;12:1584099. doi: 10.3389/fmed.2025.1584099. eCollection 2025.

DOI:10.3389/fmed.2025.1584099
PMID:40837567
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12361242/
Abstract

Uterine arteriovenous fistula (UAVF) is a rare form of uterine arteriovenous malformation, the most characteristic clinical symptom of which is intermittent vaginal bleeding. Currently, reports on the treatment of UAVF mainly focus on uterine artery embolization (UAE), high-intensity focused ultrasound (HIFU), and surgical treatment, with relatively few reports on medical conservative therapy. This article reports the process and outcomes of medical treatment for two cases of pregnancy-related acquired UAVF and summarizes and analyzes the indications and drug selection for UAVF medical conservative treatment based on the relevant literature.

摘要

子宫动静脉瘘(UAVF)是子宫动静脉畸形的一种罕见形式,其最典型的临床症状是间歇性阴道出血。目前,关于UAVF治疗的报道主要集中在子宫动脉栓塞术(UAE)、高强度聚焦超声(HIFU)和手术治疗,而关于药物保守治疗的报道相对较少。本文报道了两例妊娠相关获得性UAVF的药物治疗过程及结果,并基于相关文献总结分析了UAVF药物保守治疗的适应证及药物选择。

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本文引用的文献

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Resection of uterine arteriovenous fistula with temporary occlusion of the internal iliac arteries: Case series and literature review.子宫动静脉瘘切除术联合暂时性髂内动脉阻断:病例系列及文献复习。
Medicine (Baltimore). 2024 Aug 30;103(35):e39442. doi: 10.1097/MD.0000000000039442.
2
Danazol as a Treatment for Uterine Arteriovenous Malformation: A Case Report.达那唑治疗子宫动静脉畸形:一例报告
J Pers Med. 2023 Aug 23;13(9):1289. doi: 10.3390/jpm13091289.
3
Acquired uterine arteriovenous malformation treated with superselective embolization: Case report.
经超选择性栓塞治疗获得性子宫动静脉畸形:病例报告
Radiol Case Rep. 2023 Apr 11;18(6):2204-2208. doi: 10.1016/j.radcr.2023.03.018. eCollection 2023 Jun.
4
Uterine Arteriovenous Malformation (AVM) - a Potentially Life-Threatening Cause of Post-Partum Vaginal Bleeding.子宫动静脉畸形(AVM)——产后阴道出血的潜在致命原因。
Am J Case Rep. 2022 Dec 14;23:e938559. doi: 10.12659/AJCR.938559.
5
Uterine Artery Embolization of Uterine Arteriovenous Malformation: A Systematic Review of Success Rate, Complications, and Posterior Pregnancy Outcomes.子宫动静脉畸形的子宫动脉栓塞术:成功率、并发症及后续妊娠结局的系统评价
J Pers Med. 2022 Jul 1;12(7):1098. doi: 10.3390/jpm12071098.
6
Outcome in women undergoing uterine artery embolization for arterio-venous malformation diagnosed post-pregnancy-A retrospective study.妊娠后诊断为动静脉畸形的女性接受子宫动脉栓塞术的结局——一项回顾性研究
Turk J Obstet Gynecol. 2022 Jun 27;19(2):111-117. doi: 10.4274/tjod.galenos.2022.34683.
7
A systematic review and meta-analysis of the safety and efficacy of uterine artery embolization vs. surgery for symptomatic uterine fibroids.子宫动脉栓塞术与手术治疗症状性子宫肌瘤安全性及有效性的系统评价与荟萃分析
J Interv Med. 2019 Apr 30;1(2):112-120. doi: 10.19779/j.cnki.2096-3602.2018.02.10. eCollection 2018 May.
8
Medical Management of Uterine Arteriovenous Malformation: A Case Series.子宫动静脉畸形的医学管理:病例系列。
Eur J Obstet Gynecol Reprod Biol. 2022 Jul;274:48-55. doi: 10.1016/j.ejogrb.2022.05.005. Epub 2022 May 13.
9
Medical treatment of uterine arteriovenous malformation: a systematic review and meta-analysis.子宫动静脉畸形的治疗:系统评价和荟萃分析。
Fertil Steril. 2021 Oct;116(4):1107-1116. doi: 10.1016/j.fertnstert.2021.05.095. Epub 2021 Jun 12.
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Angiographic findings and outcomes after embolization of patients with suspected postabortion uterine arteriovenous fistula.疑似流产后子宫动静脉瘘患者栓塞治疗的血管造影表现和结局。
J Gynecol Obstet Hum Reprod. 2021 Sep;50(7):102033. doi: 10.1016/j.jogoh.2020.102033. Epub 2020 Dec 7.