Yong-Guang Shang, Wang-Jun Qin, Dong-Jie Guo, Peng-Mei Li, Lei Zhang
Department of Pharmacy, China-Japan Friendship Hospital, Beijing, China.
Front Med (Lausanne). 2025 Aug 5;12:1584286. doi: 10.3389/fmed.2025.1584286. eCollection 2025.
Medication safety remains a global public health challenge, particularly in resource-constrained primary care settings. This study aimed to develop and validate a specific, proactive, medication safety self-assessment tool tailored for primary healthcare settings in China.
A mixed-methods approach combining literature review, field investigations, a Delphi expert consultation (3 rounds), and Analytic Hierarchy Process (AHP) was implemented. Forty-three voluntarily participating settings completed the self-assessment, with effectiveness validated through correlation analysis between assessment scores and adverse drug events (ADEs) indicators (medication errors, dispensing/prescribing errors).
We constructed a medication safety self-assessment tool for primary care settings comprising 5 domains, 18 core characteristics, and 84 self-assessment items. The mean percent score for 43 participating primary care settings was 81.5% ± 11.7%, and Spearman's rank correlations were used to examine the relationship between the overall assessment scores to the incidence of ADEs (Correlation Coefficient is -0.448, = 0.003).
As the first medication safety assessment tool for Chinese primary healthcare settings, based on current medication practices and validated through ADE, implementation demonstrates potential to enhance medication safety practices.
药物安全仍然是一项全球公共卫生挑战，尤其是在资源有限的基层医疗环境中。本研究旨在开发并验证一种专门为中国基层医疗环境量身定制的、主动的药物安全自我评估工具。
采用了一种混合方法，结合文献综述、实地调查、三轮德尔菲专家咨询以及层次分析法（AHP）。43个自愿参与的机构完成了自我评估，并通过评估分数与药物不良事件（ADEs）指标（用药错误、调配/处方错误）之间的相关性分析来验证其有效性。
我们构建了一个针对基层医疗环境的药物安全自我评估工具，该工具包括5个领域、18个核心特征和84个自我评估项目。43个参与的基层医疗机构的平均得分百分比为81.5%±11.7%，并使用斯皮尔曼等级相关性来检验总体评估分数与ADEs发生率之间的关系（相关系数为-0.448，P = 0.003）。
作为首个针对中国基层医疗环境的药物安全评估工具，基于当前用药实践并通过ADE进行验证，实施该工具显示出增强用药安全实践的潜力。
