Kamilova Altinoy T, Alieva Nigora R, Akhmedova Dilorom I, Abrorova Barno T
Gastroenterology Department of Republican Specialized Scientific-Practical Medical Center of Pediatrics, Ministry of Health of Republic of Uzbekistan, Tashkent, Uzbekistan.
Hospital Pediatrics Department of Tashkent Pediatric Medical Institute, Tashkent, Uzbekistan.
Front Pediatr. 2025 Aug 5;13:1594547. doi: 10.3389/fped.2025.1594547. eCollection 2025.
The relationship between vitamin D levels and celiac disease (CeD) in children remains controversial. Uzbekistan is a country where the average number of sunny days is more than 300 days. There are few studies on the vitamin D status of children with celiac disease in an area of high insolation.
To determine vitamin D status in children with CeD and to evaluate clinical and laboratory parameters in children depending on vitamin D levels.
We examined 60 children with first diagnosed CeD aged from 1 to 16 years, the average age was 6 ± 2.3 years. The diagnosis was established on the basis of ESPGHAN 2012 criteria. In all children serum 25(OH)D, calcium, phosphorus, parathormone, alkaline phosphatase was determined. The control group consisted of 31 children of identical age.
Children with CeD had significantly lower mean serum 25(OH)D levels (14.8 ± 1.04 ng/ml) compared to controls (45.1 ± 8.04 ng/ml; < 0.001). Vitamin D deficiency (<20 ng/ml) was identified in 80% of patients with CeD, including 25% with levels <10 ng/ml. Vitamin D insufficiency was observed in 20%. Lower vitamin D levels were associated with more pronounced clinical features suggestive of metabolic imbalance, including stunting and growth retardation (observed in 41.7% and 43.8% of cases, respectively). Bone deformations were more frequent in vitamin children with D deficiency, with a significant inverse correlation between vitamin D levels and clinical bone manifestations. Serum alkaline phosphatase and parathormone levels were significantly higher in children with vitamin D deficiency and insufficiency ( < 0.05, < 0.001), with inverse correlations between vitamin D and these markers.
Children with celiac disease living in a region with increased sun light exposure showed a high prevalence of vitamin D deficiency. In our study, vitamin D deficiency in patients with celiac disease was associated with more severe clinical manifestations.
儿童维生素D水平与乳糜泻（CeD）之间的关系仍存在争议。乌兹别克斯坦是一个平均日照天数超过300天的国家。在日照充足地区，关于乳糜泻患儿维生素D状况的研究较少。
确定乳糜泻患儿的维生素D状况，并根据维生素D水平评估患儿的临床和实验室参数。
我们检查了60例首次诊断为乳糜泻的1至16岁儿童，平均年龄为6±2.3岁。诊断依据ESPGHAN 2012标准确定。测定了所有儿童的血清25(OH)D、钙、磷、甲状旁腺激素、碱性磷酸酶。对照组由31名同龄儿童组成。
与对照组（45.1±8.04 ng/ml；<0.001）相比，乳糜泻患儿的平均血清25(OH)D水平显著降低（14.8±1.04 ng/ml）。80%的乳糜泻患者存在维生素D缺乏（<20 ng/ml），其中25%的患者水平<10 ng/ml。20%的患者存在维生素D不足。较低的维生素D水平与更明显的提示代谢失衡的临床特征相关，包括发育迟缓（分别在41.7%和43.8%的病例中观察到）和生长发育迟缓。维生素D缺乏的儿童骨骼畸形更为常见，维生素D水平与临床骨骼表现之间存在显著负相关。维生素D缺乏和不足的儿童血清碱性磷酸酶和甲状旁腺激素水平显著升高（<0.05，<0.001），维生素D与这些标志物之间存在负相关。
生活在阳光照射增加地区的乳糜泻患儿维生素D缺乏患病率较高。在我们的研究中，乳糜泻患者的维生素D缺乏与更严重的临床表现相关。
