Miller Alex P, Spychala Kellyn M, Slutske Wendy S, Fromme Kim, Gizer Ian R
Department of Psychiatry, Indiana University School of Medicine.
Department of Psychological Sciences, University of Missouri.
J Psychopathol Clin Sci. 2025 Oct;134(7):775-789. doi: 10.1037/abn0001049. Epub 2025 Aug 21.
Binge drinking is a relatively common pattern of alcohol use among youth with normative trajectories peaking in emerging and early adulthood. Frequent binge drinking is a critical risk factor not only for the development of alcohol use disorders (AUDs) but also for increased odds of alcohol-related injury and death and thus constitutes a significant public health concern. Changes in binge drinking across development are strongly associated with individual differences and changes in impulsive personality traits, which have been hypothesized as intermediate phenotypes associated with genetic risk for heavy alcohol use and AUD. The current study examined the extent to which genetic influences underlying dual-systems impulsive personality traits (i.e., top-down [lack of self-control] and bottom-up [sensation seeking and urgency] constructs), alcohol consumption, and AUD are uniquely associated with longitudinal changes in binge drinking and intoxication frequency across adolescence and early adulthood. Associations were tested using conditional latent growth curve polygenic score (PGS) models in three independent longitudinal samples ( = 10,554). Results demonstrated consistent associations across all samples between sensation seeking PGSs and model intercepts (i.e., higher binge drinking frequency at first measurement occasion) and alcohol consumption PGSs and model slopes (i.e., steeper increases toward peak binge drinking frequency). Urgency PGSs were not associated with changes in binge drinking or intoxication frequency in any sample. Collectively, these findings demonstrate that genetic influences underlying sensation seeking and alcohol consumption explain unique variation in the emergence and escalation of binge drinking during adolescence and emerging adulthood, highlighting the multifaceted genetic etiology of these developmental trajectories. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
暴饮是青少年中较为常见的饮酒模式，其规范轨迹在青年期和成年早期达到峰值。频繁暴饮不仅是酒精使用障碍（AUDs）发展的关键风险因素，还会增加与酒精相关的伤害和死亡几率，因此构成了重大的公共卫生问题。整个发育过程中暴饮的变化与个体差异以及冲动型人格特质的变化密切相关，这些特质被假设为与大量饮酒和酒精使用障碍的遗传风险相关的中间表型。本研究考察了双系统冲动型人格特质（即自上而下[缺乏自我控制]和自下而上[寻求刺激和冲动性]结构）、酒精消费和酒精使用障碍背后的遗传影响在多大程度上与青少年期和成年早期暴饮和醉酒频率的纵向变化存在独特关联。在三个独立的纵向样本（N = 10,554）中使用条件潜变量增长曲线多基因评分（PGS）模型对关联进行了检验。结果表明，在所有样本中，寻求刺激PGS与模型截距（即首次测量时更高的暴饮频率）以及酒精消费PGS与模型斜率（即朝着暴饮频率峰值的更陡峭增加）之间存在一致的关联。在任何样本中，冲动性PGS与暴饮或醉酒频率的变化均无关联。总体而言，这些发现表明，寻求刺激和酒精消费背后的遗传影响解释了青少年期和成年早期暴饮出现和升级过程中的独特变异，突出了这些发育轨迹的多方面遗传病因。（PsycInfo数据库记录（c）2025美国心理学会，保留所有权利）
