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64例川崎病的前瞻性研究

[Prospective study of 64 cases of Kawasaki's disease].

作者信息

Lacroix J, Lapointe N, Weber M, Rousseau E, Van Doesburg N, Jacob J L, Chad Z

出版信息

Arch Fr Pediatr. 1985 Nov;42(9):771-6.

PMID:4083979
Abstract

We prospectively studied 64 children with Kawasaki disease. The well recognized signs were seen, but we also found hyperemia of the tympanic membrane in 27%, uveitis in 17%, syndrome of inappropriate secretion of anti-diuretic hormone in 9%, hydrops of the gallbladder in 8%, pulmonary infiltrations in 5% and one death. One patient presented with acute kidney failure, another one presented with stenosis of the renal artery, and 8 presented white blood cells (WBC) in the urinary sediment. Sedimentation was accelerated and there was an important decrease in hemoglobin blood level around the 5th day of illness. The WBC count rose around the 10th day; thereafter, all these results returned to normal while platelets counts rose. Albumin blood level was low, and all the following data were higher than normal: alpha-1-globulin, alpha-2-globulin, IgA, IgM, SGOT, SGPT, bilirubin and CRP. Viral studies were performed in 37 patients; 12 showed positive results.

摘要

我们对64例川崎病患儿进行了前瞻性研究。观察到了一些公认的体征,但我们还发现27%的患儿有鼓膜充血,17%有葡萄膜炎,9%有抗利尿激素分泌不当综合征,8%有胆囊积液,5%有肺部浸润,并有1例死亡。1例患儿出现急性肾衰竭,另1例有肾动脉狭窄,8例尿沉渣中有白细胞。血沉加快,发病第5天左右血红蛋白水平显著下降。白细胞计数在第10天左右升高;此后,所有这些结果恢复正常,而血小板计数升高。血白蛋白水平较低,以下各项数据均高于正常:α1球蛋白、α2球蛋白、IgA、IgM、谷草转氨酶、谷丙转氨酶、胆红素和C反应蛋白。对37例患者进行了病毒学研究;12例结果呈阳性。

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