[抗地高辛抗体在婴儿洋地黄中毒中的应用]
[Use of anti-digoxin antibodies in digitalis poisoning in an infant].
作者信息
Autret E, Chantepie A, Bloc D, Schermann J M, Filly M, Breteau M, Vincent J L, Laugier J
出版信息
Arch Fr Pediatr. 1985 Nov;42(9):803-4.
PMID:4083984
Abstract
Digitalis poisoning is rare, always iatrogenic and potentially lethal in infants. We report one case of severe poisoning in which treatment with digoxin Fab antibody fragments was successful. Evolution of plasma digitoxin levels showed an initial rapid decrease (T 1/2:1 hour), then a slower decline (T 1/2:5.5 days). No undesirable side-effects were observed.
摘要
洋地黄中毒在婴儿中罕见，且总是医源性的，有潜在致命性。我们报告一例严重中毒病例，其中用地高辛Fab抗体片段治疗成功。血浆洋地黄毒苷水平的变化显示，起初迅速下降（半衰期：1小时），然后下降较慢（半衰期：5.5天）。未观察到不良副作用。
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