Adegboye Oluwatobi, Din Muzammil Arif, Gilworth Jodika, Ahmed Foiz, Khatib Manaf
Faculty of Health, Education, Medicine, and Social Care, Anglia Ruskin University, Chelmsford, United Kingdom.
University of Cambridge, Cambridge, United Kingdom.
JMIR Res Protoc. 2025 Aug 21;14:e64009. doi: 10.2196/64009.
Facial paralysis is a condition that has several etiologies and is associated with significant physical and psychosocial complications. Classically, 2-stage facial reanimation was used to treat patients with unilateral facial paralysis; however, single-stage facial reanimation has seen an increase in use. Studies comparing both techniques are limited, and to the best of our knowledge, no systematic reviews have compared these techniques.
We aim to perform a systematic review that explores how the outcomes of single-stage facial reanimation with a free functional muscle flap compare against those of 2-stage facial reanimation.
This systematic review protocol has been written according to the PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols) and NICE (National Institute for Health and Care Excellence) guidelines. The search strategy will involve 3 stages: electronic databases (MEDLINE, Embase, and Web of Science Core Collection), trial registers (ClinicalTrials.gov), and snowballing. Studies published from 1995 to 2025 will be screened using inclusion and exclusion criteria. Data will be extracted into a standardized spreadsheet, and the risk of bias and quality of evidence will be assessed. Two reviewers will screen, extract, and assess the included studies. Discrepancies will be discussed and rectified with a third reviewer, if needed. A narrative synthesis of the findings will be performed and presented with descriptive and statistical analyses, where possible, using GraphPad Prism (GraphPad Software).
The review formally began in February 2025 and will be performed and reported according to this protocol and the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. A PRISMA flow diagram and checklist have been used to summarize the current search and study selection. A narrative synthesis and tables will be used to summarize the results of the included studies. Where possible, statistical analyses will be presented using graphs and figures. The final systematic review is expected to be published in December 2025.
This systematic review will aim to summarize the outcomes of the single-stage and 2-stage facial reanimation techniques and explore the differences between these surgical techniques, if any. The results will provide updated information for patients and clinicians. Moreover, the review may help identify potential areas for further research and policy development.
PROSPERO CRD42024556255; https://www.crd.york.ac.uk/PROSPERO/view/CRD42024556255.
INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): PRR1-10.2196/64009.
面瘫是一种病因多样的疾病，会引发严重的身体和心理社会并发症。传统上，两阶段面部重建术用于治疗单侧面瘫患者；然而，单阶段面部重建术的应用越来越多。比较这两种技术的研究有限，据我们所知，尚无系统评价对这些技术进行比较。
我们旨在进行一项系统评价，探讨游离功能性肌瓣单阶段面部重建术与两阶段面部重建术的效果对比情况。
本系统评价方案是根据PRISMA-P（系统评价与Meta分析方案的首选报告项目）和英国国家卫生与临床优化研究所（NICE）指南编写的。检索策略将包括三个阶段：电子数据库（MEDLINE、Embase和科学引文索引核心合集）、试验注册库（ClinicalTrials.gov）和滚雪球式检索。将使用纳入和排除标准筛选1995年至2025年发表的研究。数据将提取到标准化电子表格中，并评估偏倚风险和证据质量。两名评审员将对纳入的研究进行筛选、提取和评估。如有分歧，将进行讨论，并在需要时与第三名评审员共同修正。将对研究结果进行叙述性综合分析，并尽可能使用GraphPad Prism（GraphPad软件）进行描述性和统计分析。
该评价于2025年2月正式开始，将根据本方案和PRISMA（系统评价与Meta分析的首选报告项目）指南进行实施和报告。已使用PRISMA流程图和清单来总结当前的检索和研究选择情况。将使用叙述性综合分析和表格来总结纳入研究的结果。如有可能，将使用图表展示统计分析结果。最终的系统评价预计于2025年12月发表。
本系统评价旨在总结单阶段和两阶段面部重建技术的效果，并探讨这些手术技术之间的差异（如有）。研究结果将为患者和临床医生提供最新信息。此外，该评价可能有助于确定进一步研究和政策制定的潜在领域。
PROSPERO CRD42024556255；https://www.crd.york.ac.uk/PROSPERO/view/CRD42024556255。
国际注册报告识别号（IRRID）：PRR1-10.2196/64009。
