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[镧对角膜后上皮细胞微绒毛的损伤及其触发机制]

[Lanthanum-induced damage to microvilli in cells of the posterior epithelium of the cornea and its trigger mechanism].

作者信息

Virnik V L

出版信息

Arkh Anat Gistol Embriol. 1985 Oct;89(10):35-41.

PMID:4084073
Abstract

Destructions in filament-membranous connections of microvilli of cells of the rabbit corneal posterior epithelium have been investigated after the effect of an ionized form of lanthanum. Rare-earth ions are used as a specific antagonist and as a substituent for calcium on the surface of biopolymeres. Twelve corneas from 6 rabbits of Shinshilla strain at the age of 2 months are used. Lanthanum ions are stated to have selective connections with the luminal part of the plasmolemma and with the membrane of the microvilli in the cells of the corneal posterior epithelium. The changes in the microvilli are accompanied with destruction of the filament-membranous connections producing protrusions and vesiculation of their plasmolemma, disaggregation of microfilaments adjoining the luminal part of the cellular plasmolemma. A suggestion is made on an impostant role of calcium and C++-binding biopolymeres in the mechanism regulating the filament-membranous connections.

摘要

在镧离子化形式作用后,对兔角膜后上皮细胞微绒毛的丝状-膜状连接的破坏情况进行了研究。稀土离子被用作生物聚合物表面钙的特异性拮抗剂和替代物。使用了6只2月龄新罗西斯兔的12只角膜。镧离子被认为与角膜后上皮细胞的质膜腔部和微绒毛膜有选择性连接。微绒毛的变化伴随着丝状-膜状连接的破坏,导致其质膜出现突起和囊泡化,与细胞质膜腔部相邻的微丝解聚。有人提出钙和结合钙离子的生物聚合物在调节丝状-膜状连接的机制中起重要作用。

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Arkh Anat Gistol Embriol. 1985 Oct;89(10):35-41.
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