Gross D R, Kramer W G, Gentile B J, Welch D W, Fife W P
Aviat Space Environ Med. 1985 Dec;56(12):1203-8.
Five different experiments were conducted to determine if estimated liver plasma flow and/or plasma volume were changed as a result of exposure to 2.8 atmospheres absolute (ATA) while breathing 100% oxygen or 6 ATA while breathing compressed air. The experiments were designed to separate the relative roles of the ambient pressure, the partial pressure of oxygen, the time of high oxygen exposure or some combination of these factors on any observed changes. We found that time was not a factor in the changes seen. Hyperbaria resulted in a decrease in estimated liver plasma flow at all pressures greater than 1 ATA. There was an apparent increase in plasma volume at 1.3 ATA and a return towards 1 ATA values at higher pressures. Hyperoxia resulted in a decrease in estimated liver plasma flow at 975 mm Hg but not at 912 mm Hg. The flow was then increased again at 2128 mm Hg. Plasma volume decreased significantly at 912 mm Hg returned to baseline (152 mm Hg) values at 975 mm Hg and then decreased again at 1054 and 2128 mm Hg PO2.
进行了五项不同的实验，以确定在呼吸100%氧气时暴露于2.8绝对大气压（ATA）或呼吸压缩空气时暴露于6 ATA的情况下，估计的肝脏血浆流量和/或血浆容量是否发生了变化。这些实验旨在区分环境压力、氧气分压、高氧暴露时间或这些因素的某种组合对任何观察到的变化的相对作用。我们发现时间不是观察到的变化中的一个因素。高压环境导致在所有大于1 ATA的压力下，估计的肝脏血浆流量下降。在1.3 ATA时血浆容量明显增加，在更高压力下又恢复到接近1 ATA时的值。高氧导致在975毫米汞柱时估计的肝脏血浆流量下降，但在912毫米汞柱时没有下降。然后在2128毫米汞柱时流量再次增加。血浆容量在912毫米汞柱时显著下降，在975毫米汞柱时恢复到基线（152毫米汞柱）值，然后在1054和2128毫米汞柱的氧分压下再次下降。
