Kramer W G, Gross D R, Fife W P, Chaikin B N
Res Commun Chem Pathol Pharmacol. 1981 Dec;34(3):381-8.
The effect of hyperbaria and hyperbaric hyperoxia on the disposition kinetics of theophylline were investigated in the dog. The drug was administered as a 5 mg/kg iv bolus at 1 atmospheres absolute (ATA), 2.8 ATA and 6 ATA. Serial blood samples were collected over an eight hour period and analyzed for theophylline concentration using a gas chromatographic method. From the resultant data, elimination half-life, volume of distribution and total body clearance were calculated. There were no apparent effects of hyperbaria or hyperbaric hyperoxia on any of the parameters describing theophylline disposition, implying that, in the animal model studied, distribution, elimination and effect should remain constant.
在犬类动物中研究了高压和高压高氧对茶碱处置动力学的影响。在绝对1个大气压（ATA）、2.8 ATA和6 ATA条件下，以5 mg/kg静脉推注的方式给药。在8小时内采集系列血样，并采用气相色谱法分析茶碱浓度。根据所得数据计算消除半衰期、分布容积和全身清除率。高压或高压高氧对描述茶碱处置的任何参数均无明显影响，这意味着在所研究的动物模型中，分布、消除及效应应保持恒定。
