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不同运动模式对轻度认知障碍成年人的疗效比较:一项网状Meta分析

Comparison of the Efficacy of Different Exercise Modes on MCI Adults: A Network Meta-Analysis.

作者信息

Qiu Changjiang, Han Jiaxin, Xie Yao, Liu Lu, Zeng Yufeng, Xiao Liangyi, Zeng Shanshan, Xie Le, Wu Dahua

机构信息

Hunan University of Chinese Medicine, Changsha, China.

Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine (The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine), Changsha, China.

出版信息

Brain Behav. 2025 Aug;15(8):e70734. doi: 10.1002/brb3.70734.


DOI:10.1002/brb3.70734
PMID:40842144
Abstract

BACKGROUND: Mild cognitive impairment (MCI) is considered a preclinical or prodromal stage of Alzheimer's disease (AD). MCI patients have an annual probability of progression to dementia of 10%-15%, far higher than the normal elderly (∼1%-2%). We conducted a network meta-analysis (NMA) on the efficacy of various exercise modes on MCI adults. METHODS: A computer search was conducted in Embase, PubMed, the Cochrane Library, and Web of Science for RCTs on the effects of exercise training on MCI patients from their inception to February 22, 2025. Two reviewers were independently responsible for study screening, data extraction, and quality assessment. RevMan 5.4, Stata15, and R4.4.1 were utilized for data analysis. RESULTS: Thirty-five studies with 2717 patients were included. The NMA results revealed that combination training (CT) performed best in increasing the MoCA and MMSE scores of MCI patients, with SUCRA of 99.43% and 87.04%, respectively. Resistance training and sensorimotor training were the second-best interventions for increasing MMSE and MoCA scores, respectively. CONCLUSION: CT is the best intervention to improve MOCA and MMSE scores in patients with MCI, which can effectively alleviate the disease progression of MCI. However, a variety of double-blind, large-sample clinical trials are still needed to further verify this conclusion.

摘要

背景:轻度认知障碍(MCI)被认为是阿尔茨海默病(AD)的临床前或前驱阶段。MCI患者每年进展为痴呆的概率为10%-15%,远高于正常老年人(约1%-2%)。我们对各种运动模式对MCI成年人的疗效进行了网络荟萃分析(NMA)。 方法:在Embase、PubMed、Cochrane图书馆和Web of Science中进行计算机检索,以查找从开始到2025年2月22日关于运动训练对MCI患者影响的随机对照试验(RCT)。两名 reviewers 独立负责研究筛选、数据提取和质量评估。使用RevMan 5.4、Stata15和R4.4.1进行数据分析。 结果:纳入了35项研究,共2717例患者。NMA结果显示,联合训练(CT)在提高MCI患者的MoCA和MMSE评分方面表现最佳,SUCRA分别为99.43%和87.04%。阻力训练和感觉运动训练分别是提高MMSE和MoCA评分的次优干预措施。 结论:CT是改善MCI患者MOCA和MMSE评分的最佳干预措施,可有效缓解MCI的疾病进展。然而,仍需要各种双盲、大样本的临床试验来进一步验证这一结论。

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本文引用的文献

[1]
Effects of Dance-Based Aerobic Training on Frailty and Cognitive Function in Older Adults with Mild Cognitive Impairment: A Randomized Controlled Trial.

Diagnostics (Basel). 2025-2-3

[2]
Effect of Tai Chi combined with music therapy on the cognitive function in older adult individuals with mild cognitive impairment.

Front Public Health. 2025-1-28

[3]
Effect of an Aerobic Dancing Program on Sleep Quality for Older Adults With Mild Cognitive Impairment and Poor Sleep: A Randomized Controlled Trial.

J Am Med Dir Assoc. 2023-10-26

[4]
Effects of Sitting Baduanjin Exercises on Cognitive Function, Attention, and Muscle Strength among Patients with Mild Cognitive Impairment.

J Community Health Nurs. 2025

[5]
Effects of a dual intervention (motor and virtual reality-based cognitive) on cognition in patients with mild cognitive impairment: a single-blind, randomized controlled trial.

J Neuroeng Rehabil. 2024-8-1

[6]
The cerebellum and the Mirror Neuron System: A matter of inhibition? From neurophysiological evidence to neuromodulatory implications. A narrative review.

Neurosci Biobehav Rev. 2024-9

[7]
Effects of low-intensity home-based exercise on cognition in older persons with mild cognitive impairment: a direct comparison of aerobic versus resistance exercises using a randomized controlled trial design.

Front Med (Lausanne). 2024-6-21

[8]
Effects of dual-task resistance exercise on cognition, mood, depression, functional fitness, and activities of daily living in older adults with cognitive impairment: a single-blinded, randomized controlled trial.

BMC Geriatr. 2024-4-24

[9]
Effects of square dance exercise on cognitive function in elderly individuals with mild cognitive impairment: the mediating role of balance ability and executive function.

BMC Geriatr. 2024-2-15

[10]
The effects of different exercise types on cognitive and physical functions in dementia patients: A randomized comparative study.

Arch Gerontol Geriatr. 2024-4

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