Qiu Changjiang, Han Jiaxin, Xie Yao, Liu Lu, Zeng Yufeng, Xiao Liangyi, Zeng Shanshan, Xie Le, Wu Dahua
Hunan University of Chinese Medicine, Changsha, China.
Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine (The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine), Changsha, China.
Brain Behav. 2025 Aug;15(8):e70734. doi: 10.1002/brb3.70734.
BACKGROUND: Mild cognitive impairment (MCI) is considered a preclinical or prodromal stage of Alzheimer's disease (AD). MCI patients have an annual probability of progression to dementia of 10%-15%, far higher than the normal elderly (∼1%-2%). We conducted a network meta-analysis (NMA) on the efficacy of various exercise modes on MCI adults. METHODS: A computer search was conducted in Embase, PubMed, the Cochrane Library, and Web of Science for RCTs on the effects of exercise training on MCI patients from their inception to February 22, 2025. Two reviewers were independently responsible for study screening, data extraction, and quality assessment. RevMan 5.4, Stata15, and R4.4.1 were utilized for data analysis. RESULTS: Thirty-five studies with 2717 patients were included. The NMA results revealed that combination training (CT) performed best in increasing the MoCA and MMSE scores of MCI patients, with SUCRA of 99.43% and 87.04%, respectively. Resistance training and sensorimotor training were the second-best interventions for increasing MMSE and MoCA scores, respectively. CONCLUSION: CT is the best intervention to improve MOCA and MMSE scores in patients with MCI, which can effectively alleviate the disease progression of MCI. However, a variety of double-blind, large-sample clinical trials are still needed to further verify this conclusion.
背景:轻度认知障碍(MCI)被认为是阿尔茨海默病(AD)的临床前或前驱阶段。MCI患者每年进展为痴呆的概率为10%-15%,远高于正常老年人(约1%-2%)。我们对各种运动模式对MCI成年人的疗效进行了网络荟萃分析(NMA)。 方法:在Embase、PubMed、Cochrane图书馆和Web of Science中进行计算机检索,以查找从开始到2025年2月22日关于运动训练对MCI患者影响的随机对照试验(RCT)。两名 reviewers 独立负责研究筛选、数据提取和质量评估。使用RevMan 5.4、Stata15和R4.4.1进行数据分析。 结果:纳入了35项研究,共2717例患者。NMA结果显示,联合训练(CT)在提高MCI患者的MoCA和MMSE评分方面表现最佳,SUCRA分别为99.43%和87.04%。阻力训练和感觉运动训练分别是提高MMSE和MoCA评分的次优干预措施。 结论:CT是改善MCI患者MOCA和MMSE评分的最佳干预措施,可有效缓解MCI的疾病进展。然而,仍需要各种双盲、大样本的临床试验来进一步验证这一结论。
Cochrane Database Syst Rev. 2021-4-19
Cochrane Database Syst Rev. 2017-12-22
Cochrane Database Syst Rev. 2020-1-9
Cochrane Database Syst Rev. 2021-11-8
Cochrane Database Syst Rev. 2017-4-18
Cochrane Database Syst Rev. 2017-1-27