Chen Zilin, Wang Xu, Hu Yuchen, Zhang Si, Han Fei
Department of Pediatrics, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Front Cell Neurosci. 2025 Aug 6;19:1623576. doi: 10.3389/fncel.2025.1623576. eCollection 2025.
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that manifests in early childhood, with its specific causes and pathogenesis remaining incompletely understood. The gut bacteria plays a pivotal role in host health and neurodevelopment. Maternal eating disorders may disrupt maternal gut bacteria and subsequently influence fetal and neonatal gut bacteria through the gut-placental axis and breastfeeding. This disruption can ultimately impact the microbial-gut-brain axis, the immune system, neurotransmitter dysregulation, and metabolite abnormalities, thereby increasing the risk of ASD in offspring. This paper reviews the adverse effects of bad maternal dietary habits, including high-sugar, high-salt, high-fat diets, alcohol consumption, dietary fiber deficiency, and the intake of ultra-processed foods, on the gut bacteria. It also explores the mechanisms by which gut microbiota disorder may induce ASD through the immune system, neurotransmitters, and metabolites. Additionally, the article proposes potential strategies to prevent ASD by adjusting dietary structures and enhancing gut bacteria health.
自闭症谱系障碍(ASD)是一种在幼儿期出现的神经发育障碍,其具体病因和发病机制仍未完全明确。肠道细菌在宿主健康和神经发育中起着关键作用。母体饮食失调可能会破坏母体肠道细菌,随后通过肠-胎盘轴和母乳喂养影响胎儿和新生儿的肠道细菌。这种破坏最终会影响微生物-肠-脑轴、免疫系统、神经递质失调和代谢物异常,从而增加后代患自闭症谱系障碍的风险。本文综述了不良的母体饮食习惯,包括高糖、高盐、高脂饮食、饮酒、膳食纤维缺乏以及超加工食品的摄入,对肠道细菌的不良影响。还探讨了肠道微生物群紊乱可能通过免疫系统、神经递质和代谢物诱发自闭症谱系障碍的机制。此外,文章提出了通过调整饮食结构和增强肠道细菌健康来预防自闭症谱系障碍的潜在策略。
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