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母体饮食对后代肠道细菌及自闭症谱系障碍的影响。

Effect of maternal diet on gut bacteria and autism spectrum disorder in offspring.

作者信息

Chen Zilin, Wang Xu, Hu Yuchen, Zhang Si, Han Fei

机构信息

Department of Pediatrics, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.

出版信息

Front Cell Neurosci. 2025 Aug 6;19:1623576. doi: 10.3389/fncel.2025.1623576. eCollection 2025.


DOI:10.3389/fncel.2025.1623576
PMID:40842563
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12364926/
Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder that manifests in early childhood, with its specific causes and pathogenesis remaining incompletely understood. The gut bacteria plays a pivotal role in host health and neurodevelopment. Maternal eating disorders may disrupt maternal gut bacteria and subsequently influence fetal and neonatal gut bacteria through the gut-placental axis and breastfeeding. This disruption can ultimately impact the microbial-gut-brain axis, the immune system, neurotransmitter dysregulation, and metabolite abnormalities, thereby increasing the risk of ASD in offspring. This paper reviews the adverse effects of bad maternal dietary habits, including high-sugar, high-salt, high-fat diets, alcohol consumption, dietary fiber deficiency, and the intake of ultra-processed foods, on the gut bacteria. It also explores the mechanisms by which gut microbiota disorder may induce ASD through the immune system, neurotransmitters, and metabolites. Additionally, the article proposes potential strategies to prevent ASD by adjusting dietary structures and enhancing gut bacteria health.

摘要

自闭症谱系障碍(ASD)是一种在幼儿期出现的神经发育障碍,其具体病因和发病机制仍未完全明确。肠道细菌在宿主健康和神经发育中起着关键作用。母体饮食失调可能会破坏母体肠道细菌,随后通过肠-胎盘轴和母乳喂养影响胎儿和新生儿的肠道细菌。这种破坏最终会影响微生物-肠-脑轴、免疫系统、神经递质失调和代谢物异常,从而增加后代患自闭症谱系障碍的风险。本文综述了不良的母体饮食习惯,包括高糖、高盐、高脂饮食、饮酒、膳食纤维缺乏以及超加工食品的摄入,对肠道细菌的不良影响。还探讨了肠道微生物群紊乱可能通过免疫系统、神经递质和代谢物诱发自闭症谱系障碍的机制。此外,文章提出了通过调整饮食结构和增强肠道细菌健康来预防自闭症谱系障碍的潜在策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f44/12364926/b7c3491fd9b6/fncel-19-1623576-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f44/12364926/c1fa910fb3f1/fncel-19-1623576-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f44/12364926/498171e600bf/fncel-19-1623576-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f44/12364926/b7c3491fd9b6/fncel-19-1623576-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f44/12364926/c1fa910fb3f1/fncel-19-1623576-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f44/12364926/498171e600bf/fncel-19-1623576-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f44/12364926/b7c3491fd9b6/fncel-19-1623576-g003.jpg

相似文献

[1]
Effect of maternal diet on gut bacteria and autism spectrum disorder in offspring.

Front Cell Neurosci. 2025-8-6

[2]
Gut microbiota and autism spectrum disorder: advances in dietary intervention strategies based on the microbiota-gut-brain axis mechanism.

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[3]
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[4]
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[5]
Autism Spectrum and gastrointestinal health: Screening on the influence of environmental factors on gastrointestinal problems.

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[6]
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[7]
Impact of maternal microbiota imbalance during pregnancy on fetal cerebral neurodevelopment: Is there a link to certain autistic disorders?

Brain Behav Immun Health. 2025-7-28

[8]
Pharmaco-psychiatry and gut microbiome: a systematic review of effects of psychotropic drugs for bipolar disorder.

Microbiology (Reading). 2025-6

[9]
The impact of early-life exposures on growth and adult gut microbiome composition is dependent on genetic strain and parent- of- origin.

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[10]
Anti-Inflammatory Diet and Probiotic Supplementation as Strategies to Modulate Immune Dysregulation in Autism Spectrum Disorder.

Nutrients. 2025-8-18

本文引用的文献

[1]
Dynamic changes in the gut microbiota of SPF Bama piglets during breast and formula feeding.

Front Microbiol. 2025-2-26

[2]
Common Gut Microbial Signatures in Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder.

Autism Res. 2025-4

[3]
Autism Spectrum and gastrointestinal health: Screening on the influence of environmental factors on gastrointestinal problems.

Autism Res. 2024-12

[4]
Glibenclamide reverses cardiac damage and NLRP3 inflammasome activation associated with a high refined sugar diet.

Eur J Pharmacol. 2024-12-5

[5]
High-sugar diet leads to loss of beneficial probiotics in housefly larvae guts.

ISME J. 2024-1-8

[6]
Akkermansia muciniphila improve cognitive dysfunction by regulating BDNF and serotonin pathway in gut-liver-brain axis.

Microbiome. 2024-9-28

[7]
Galangin Alleviates Alcohol-Provoked Liver Injury Associated with Gut Microbiota Disorder and Intestinal Barrier Dysfunction in Mice.

J Agric Food Chem. 2024-10-9

[8]
Intervention in gut microbiota increases intestinal γ-aminobutyric acid and alleviates anxiety behavior: a possible mechanism via the action on intestinal epithelial cells.

Front Cell Infect Microbiol. 2024

[9]
Analysis of Gut Bacterial and Fungal Microbiota in Children with Autism Spectrum Disorder and Their Non-Autistic Siblings.

Nutrients. 2024-9-5

[10]
Intrauterine Shaping of Fetal Microbiota.

J Clin Med. 2024-9-9

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