Adak Souvik, Singh Shivam, Jain Ridhi, Tiwari Abhilasha, Singh Binny, Kumar Sumit, Dadhwal Ayushi, Chakroborty Avishek, Sharma Ashish Kumar, Singh Ravindra Pal, Sharma Rajesh Kumar
NIMS Institute of Pharmacy, NIMS University, Jaipur, India.
Front Aging Neurosci. 2025 Aug 6;17:1646551. doi: 10.3389/fnagi.2025.1646551. eCollection 2025.
Alzheimer's disease (AD) is a chronic and progressive neurodegenerative condition that worsens with time and causes memory loss and cognitive impairment. For prompt intervention and management of AD, early detection is essential. Screening models play a crucial role in identifying individuals at risk of developing AD before the onset of noticeable clinical symptoms. This review summarizes a wide range of and screening models currently utilized in AD research, highlighting their advantages and limitations. systems-such as cell lines and primary neuronal cultures-provide controlled settings to investigate cellular mechanisms and drug efficacy. In contrast, models, including transgenic rodents and other animals, better replicate the complex biological features of AD. Each model type comes with distinct benefits and limitations concerning clinical relevance, cost-effectiveness, and ethical challenges. By evaluating the utility and constrains of these models, this article seeks to assist researchers in choosing suitable platforms for preclinical investigations and support the advancement of improved diagnostic tools and therapeutic strategies for AD.
阿尔茨海默病（AD）是一种慢性进行性神经退行性疾病，会随着时间的推移而恶化，并导致记忆丧失和认知障碍。对于AD的及时干预和管理，早期检测至关重要。筛查模型在识别出现明显临床症状之前有患AD风险的个体方面起着关键作用。本综述总结了目前AD研究中广泛使用的各种筛查模型，突出了它们的优点和局限性。细胞系和原代神经元培养等系统提供了可控的环境来研究细胞机制和药物疗效。相比之下，转基因啮齿动物和其他动物等模型能更好地复制AD的复杂生物学特征。每种模型类型在临床相关性、成本效益和伦理挑战方面都有独特的优点和局限性。通过评估这些模型的效用和限制，本文旨在帮助研究人员选择适合临床前研究的平台，并支持改进AD诊断工具和治疗策略的进展。
