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大鼠心室肌停顿后收缩的年龄依赖性

Age dependence of post-pause contractions in the ventricular myocardium of rats.

作者信息

Pfeiffer C, Huckstorf C

出版信息

Biomed Biochim Acta. 1985;44(9):1343-9.

PMID:4084280
Abstract

The maximal post-pause contraction has been measured in random bred albino rats by varying the contraction interval preceding this event. The amplitude of the maximal post-pause contraction as well as the duration of the pause interval corresponding to this contraction depend on the driving frequency applied just prior to this pause. The amplitude increases whereas the duration of the appropriate interval shortens when the driving frequency is increased. Both parameters are also influenced by the age of the tested animals; they increase from the 6th to the 15th week of life if the driving frequency is low. The effects are explained by the assumption that the circulation of the activator calcium is transferred from extracellular more to intracellular storage sites during maturation of the myocardium.

摘要

通过改变最大后暂停收缩事件之前的收缩间隔,在随机繁殖的白化大鼠中测量了最大后暂停收缩。最大后暂停收缩的幅度以及与此收缩相对应的暂停间隔的持续时间取决于紧接此暂停之前施加的驱动频率。当驱动频率增加时,幅度增加而相应间隔的持续时间缩短。这两个参数也受受试动物年龄的影响;如果驱动频率较低,它们在出生后第6周到第15周会增加。这些效应可以通过以下假设来解释:在心肌成熟过程中,激活钙的循环从细胞外更多地转移到细胞内储存部位。

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